Cell-mediated immunity to liver antigen in toxic liver injury. II. Role in pathogenesis of liver damage

Smith C.I., Cooksley W.G.E. and Powell L.W. (1980) Cell-mediated immunity to liver antigen in toxic liver injury. II. Role in pathogenesis of liver damage. Clinical and Experimental Immunology, 39 3: 618-625.

Author Smith C.I.
Cooksley W.G.E.
Powell L.W.
Title Cell-mediated immunity to liver antigen in toxic liver injury. II. Role in pathogenesis of liver damage
Journal name Clinical and Experimental Immunology   Check publisher's open access policy
ISSN 0009-9104
Publication date 1980-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 39
Issue 3
Start page 618
End page 625
Total pages 8
Language eng
Subject 2403 Immunology
Abstract The possible pathogenetic role of lymphocytes sensitized to liver antigens was investigated in CBA mice in which sublethal CCl necrosis had been by carbon tetrachloride (CCl). Sensitized lymphocytes from CCl- treated mice were administered to syngeneic recipients. The recipients developed sensitivity to liver antigens but showed no evidence of liver damage. The cell mediating the immune response both in the donor and the recipient was a T cell. This was demonstrated further by studies involving mice rendered T cell deficient. These mice did not develop sensitized lymphocytes when they were treated with CCl but the extent of liver damage was similar in both T cell-depleted and intact animals. These findings suggest that T cell sensitization to liver antigens occurs as a result of toxic liver damage and does not play a role in the pathogenesis of the hepatic necrosis.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 06 Sep 2016, 10:53:22 EST by System User