A comparative study of collagen induced thromboxane release from platelets of different species: Implications for human athero sclerosis models

Leach C.M. and Thorburn G.D. (1982) A comparative study of collagen induced thromboxane release from platelets of different species: Implications for human athero sclerosis models. Prostaglandins, 24 1: 47-59. doi:10.1016/0090-6980(82)90176-9


Author Leach C.M.
Thorburn G.D.
Title A comparative study of collagen induced thromboxane release from platelets of different species: Implications for human athero sclerosis models
Journal name Prostaglandins   Check publisher's open access policy
ISSN 0090-6980
Publication date 1982-01-01
Sub-type Article (original research)
DOI 10.1016/0090-6980(82)90176-9
Open Access Status Not yet assessed
Volume 24
Issue 1
Start page 47
End page 59
Total pages 13
Subject 1303 Specialist Studies in Education
1310 Endocrinology
Abstract The role of thromboxane in human, rabbit, dog, pig and sheep platelet aggregation has been studied. Each of these species showed a concentration-dependent relationship between collagen concentrations and the thromboxane B2 (TXB2) released from aggregating platelets, however sheep platelets produced only 17.5% of the amount of TXB2 released from human platelets under the same collagen stimulus. Indomethacin did not inhibit sheep platelet aggregation in the concentration range 0.114 mM - 0.114 μM, yet proved to be a potent inhibitor of human platelet aggregation. This prostaglandin endoperoxide analogue, U.46619, induced human platelet aggregation at a dose of 100 ng, however the analouge, at doses as high as 500 μg was much less active on sheep platelets when compared to human platelets. Thus we have demonstrated that there are differences in the extent of thromboxane involvement in platelet aggregation between different species, which must be considered with other criteria, before choosing an animal model for studying human atherosclerosis.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 06 Sep 2016, 10:49:57 EST by System User