A paucity of palindromes in φX174

Duggleby R.G. (1981) A paucity of palindromes in φX174. Journal of Theoretical Biology, 93 1: 143-155. doi:10.1016/0022-5193(81)90061-8

Author Duggleby R.G.
Title A paucity of palindromes in φX174
Journal name Journal of Theoretical Biology   Check publisher's open access policy
ISSN 1095-8541
Publication date 1981-11-07
Sub-type Article (original research)
DOI 10.1016/0022-5193(81)90061-8
Open Access Status Not yet assessed
Volume 93
Issue 1
Start page 143
End page 155
Total pages 13
Subject 1100 Agricultural and Biological Sciences
Abstract The nucleotide sequence of the bacteriophage φX174 contains surprisingly few restriction endonuclease recognition sites. The observed frequency of those sites which consist of a six-nucleotide palindromic sequence would occur by chance with a probability of less than 8 × 10-5. The genome of φX174 does not contain the four-nucleotide palindromic recognition site for the enzyme MboI and this finding has a probability of only 1·7 × 10-9. A further analysis of the nucleotide sequence revealed that there is a marked scarcity of palindromic sequences with a length of four or six nucleotides while all other palindromes occur with a frequency close to that dictated by chance. A preliminary analysis of the genomes of other DNA viruses indicated that this palindrome avoidance is associated with single-stranded viruses only. The reasons for the paucity of these short even-numbered palindromes remains to be determined.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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