Possible organ and age-related epigenetic factors in Huntington's disease and colorectal carcinoma

Ferluga J. (1989) Possible organ and age-related epigenetic factors in Huntington's disease and colorectal carcinoma. Medical Hypotheses, 29 1: 51-54. doi:10.1016/0306-9877(89)90168-0


Author Ferluga J.
Title Possible organ and age-related epigenetic factors in Huntington's disease and colorectal carcinoma
Journal name Medical Hypotheses   Check publisher's open access policy
ISSN 0306-9877
Publication date 1989-01-01
Sub-type Article (original research)
DOI 10.1016/0306-9877(89)90168-0
Open Access Status Not yet assessed
Volume 29
Issue 1
Start page 51
End page 54
Total pages 4
Subject 1309 Developmental Biology
2700 Medicine
3002 Drug Discovery
Abstract It is hypothesized that the expression of Huntington's disease and the development of sporadic colorectal carcinomas may largely depend on age-related epigenetic defects in methylation pattern of DNA at the disease associated loci. In the former case the potential defects may be coupled with a DNA demethylation and activation in the brain of a silent growth factor-like gene that may induce an abnormal cell differentiation. In the development of colon carcinomas the age-related process may affect potential growth regulatory genes that may normally become demethylated and active in the colon as part of their differential expression. In such a state and possibly also due to their structure, they may be especially prone to the epigenetic defects that may lead in this case to gene point mutation and deletion.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
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