A USPIO doped gel phantom for R2* relaxometry

Brown, Gregory C., Cowin, Gary J. and Galloway, Graham J. (2016) A USPIO doped gel phantom for R2* relaxometry. Magnetic Resonance Materials in Physics, Biology and Medicine, 30 1: 1-13. doi:10.1007/s10334-016-0576-x

Author Brown, Gregory C.
Cowin, Gary J.
Galloway, Graham J.
Title A USPIO doped gel phantom for R2* relaxometry
Formatted title
A USPIO doped gel phantom for R2* relaxometry
Journal name Magnetic Resonance Materials in Physics, Biology and Medicine   Check publisher's open access policy
ISSN 0968-5243
Publication date 2016-07-19
Sub-type Article (original research)
DOI 10.1007/s10334-016-0576-x
Open Access Status Not yet assessed
Volume 30
Issue 1
Start page 1
End page 13
Total pages 13
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2017
Language eng
Formatted abstract
Objective: This work describes a phantom containing regions of controlled R2* (1/T2*) values to provide a stable reference object for testing implementations of R2* relaxometry commonly used for liver and heart iron assessments.

Materials and methods: A carrageenan-strengthened gadolinium DTPA doped agarose gel was used to enclose nine gels additionally doped with ultra-small superparamagnetic iron oxide. R2* values were determined at 1.5 T using multi-echo GRE sequences and exponential regression of pixel values from a region of interest against echo time using non-linear regression algorithms. We measured R2*, R2 and R1 values and the inter-scan and inter-operator reproducibility.

Results: The phantom reliably demonstrated R2* values in seven steps between 22.4 s−1 (SE 1.98) and 441.9 s−1 (SE 6.76), with an R2* relaxivity (r2*) of 792 (SE 5.6) mM−1 s−1. The doped gels displayed a concentration-dependent R2สน component of R2* phantom, indicating superparamagnetic enhancement effects. We observed no significant change in relaxivity (r2*) over 12 months, and estimate a useful life of 3 years. Detailed descriptions of the production process and calculators are been provided as Online Resources.

The phantom provides a durable test object with controlled R2* relaxation behaviour, useful for a range of R2* relaxometry reference work.
Keyword Calibration
Quantitative evaluation
Phantom imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
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Created: Tue, 06 Sep 2016, 02:15:08 EST by Gregory Brown on behalf of Queensland Brain Institute