Insight into rheumatological cause and effect through the use of Mendelian randomization

Robinson, Philip C., Choi, Hyon K., Do, Ron and Merriman, Tony R. (2016) Insight into rheumatological cause and effect through the use of Mendelian randomization. Nature Reviews Rheumatology, 12 8: 486-493. doi:10.1038/nrrheum.2016.102


Author Robinson, Philip C.
Choi, Hyon K.
Do, Ron
Merriman, Tony R.
Title Insight into rheumatological cause and effect through the use of Mendelian randomization
Journal name Nature Reviews Rheumatology   Check publisher's open access policy
ISSN 1759-4804
1759-4790
Publication date 2016-08-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrrheum.2016.102
Open Access Status Not yet assessed
Volume 12
Issue 8
Start page 486
End page 493
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2745 Rheumatology
Abstract Establishing causality of risk factors is important to determine the pathogenetic mechanisms underlying rheumatic diseases, and can facilitate the design of interventions to improve care for affected patients. The presence of unmeasured confounders, as well as reverse causation, is a challenge to the assignment of causality in observational studies. Alleles for genetic variants are randomly inherited at meiosis. Mendelian randomization analysis uses these genetic variants to test whether a particular risk factor is causal for a disease outcome. In this Review of the Mendelian randomization technique, we discuss published results and potential applications in rheumatology, as well as the general clinical utility and limitations of the approach.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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