Genome-wide association study reveals two new risk loci for bipolar disorder

Muehleisen, Thomas W., Leber, Markus, Schulze, Thomas G., Strohmaier, Jana, Degenhardt, Franziska, Treutlein, Jens, Mattheisen, Manuel, Forstner, Andreas J., Schumacher, Johannes, Breuer, Rene, Meier, Sandra, Herms, Stefan, Hoffmann, Per, Lacour, Andre, Witt, Stephanie H., Reif, Andreas, Mueller-Myhsok, Bertram, Lucae, Susanne, Maier, Wolfgang, Schwarz, Markus, Vedder, Helmut, Kammerer-Ciernioch, Jutta, Pfennig, Andrea, Bauer, Michael, Hautzinger, Martin, Moebus, Susanne, Priebe, Lutz, Czerski, Piotr M., Hauser, Joanna, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Brennan, Paul, Mckay, James D., Wright, Adam, Mitchell, Philip B., Fullerton, Janice M., Schofield, Peter R., Montgomery, Grant W., Medland, Sarah E., Gordon, Scott D., Martin, Nicholas G., Krasnow, Valery, Chuchalin, Alexander, Babadjanova, Gulja, Pantelejeva, Galina, Abramova, Lilia I., Tiganov, Alexander S., Polonikov, Alexey, Khusnutdinova, Elza, Alda, Martin, Grof, Paul, Rouleau, Guy A., Turecki, Gustavo, Laprise, Catherine, Rivas, Fabio, Mayoral, Fermin, Kogevinas, Manolis, Grigoroiu-Serbanescu, Maria, Propping, Peter, Becker, Tim, Rietschel, Marcella, Noethen, Markus M. and Cichon, Sven (2014) Genome-wide association study reveals two new risk loci for bipolar disorder. Nature Communications, 5 3339: 1-8. doi:10.1038/ncomms4339

Author Muehleisen, Thomas W.
Leber, Markus
Schulze, Thomas G.
Strohmaier, Jana
Degenhardt, Franziska
Treutlein, Jens
Mattheisen, Manuel
Forstner, Andreas J.
Schumacher, Johannes
Breuer, Rene
Meier, Sandra
Herms, Stefan
Hoffmann, Per
Lacour, Andre
Witt, Stephanie H.
Reif, Andreas
Mueller-Myhsok, Bertram
Lucae, Susanne
Maier, Wolfgang
Schwarz, Markus
Vedder, Helmut
Kammerer-Ciernioch, Jutta
Pfennig, Andrea
Bauer, Michael
Hautzinger, Martin
Moebus, Susanne
Priebe, Lutz
Czerski, Piotr M.
Hauser, Joanna
Lissowska, Jolanta
Szeszenia-Dabrowska, Neonila
Brennan, Paul
Mckay, James D.
Wright, Adam
Mitchell, Philip B.
Fullerton, Janice M.
Schofield, Peter R.
Montgomery, Grant W.
Medland, Sarah E.
Gordon, Scott D.
Martin, Nicholas G.
Krasnow, Valery
Chuchalin, Alexander
Babadjanova, Gulja
Pantelejeva, Galina
Abramova, Lilia I.
Tiganov, Alexander S.
Polonikov, Alexey
Khusnutdinova, Elza
Alda, Martin
Grof, Paul
Rouleau, Guy A.
Turecki, Gustavo
Laprise, Catherine
Rivas, Fabio
Mayoral, Fermin
Kogevinas, Manolis
Grigoroiu-Serbanescu, Maria
Propping, Peter
Becker, Tim
Rietschel, Marcella
Noethen, Markus M.
Cichon, Sven
Title Genome-wide association study reveals two new risk loci for bipolar disorder
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2014-03-11
Year available 2014
Sub-type Article (original research)
DOI 10.1038/ncomms4339
Open Access Status DOI
Volume 5
Issue 3339
Start page 1
End page 8
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 01GS08144
RI 908/7-1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 102 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 109 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 03 Sep 2016, 01:42:34 EST by System User on behalf of Institute for Molecular Bioscience