Common breast cancer susceptibility loci are associated with triple-negative breast cancer

Stevens, Kristen N., Vachon, Celine M., Lee, Adam M., Slager, Susan, Lesnick, Timothy, Olswold, Curtis, Fasching, Peter A., Miron, Penelope, Eccles, Diana, Carpenter, Jane E., Godwin, Andrew K., Ambrosone, Christine, Winqvist, Robert, Brauch, Hiltrud, Schmidt, Marjanka K., Cox, Angela, Cross, Simon S., Sawyer, Elinor, Hartmann, Arndt, Beckmann, Matthias W., Schulz-Wendtland, Ruediger, Ekici, Arif B., Tapper, William J., Gerty, Susan M., Durcan, Lorraine, Graham, Nikki, Hein, Rebecca, Nickels, Stephan, Flesch-Janys, Dieter, Heinz, Judith, Sinn, Hans-Peter, Konstantopoulou, Irene, Fostira, Florentia, Pectasides, Dimitrios, Dimopoulos, Athanasios M., Fountzilas, George, Clarke, Christine L., Balleine, Rosemary, Olson, Janet E., Fredericksen, Zachary, Diasio, Robert B., Pathak, Harsh, Ross, Eric, Weaver, JoEllen, Ruediger, Thomas, Forsti, Asta, Duennebier, Thomas, Ademuyiwa, Foluso, Kulkarni, Swati, Pylkaes, Katri, Jukkola-Vuorinen, Arja, Ko, Yon-Dschun, Van Limbergen, Erik, Janssen, Hilde, Peto, Julian, Fletcher, Olivia, Giles, Graham G., Baglietto, Laura, Verhoef, Senno, Tomlinson, Ian, Kosma, Veli-Matti, Beesley, Jonathan, Greco, Dario, Blomqvist, Carl, Irwanto, Astrid, Liu, Jianjun, Blows, Fiona M., Dawson, Sarah-Jane, Margolin, Sara, Mannermaa, Arto, Martin, Nicholas G., Montgomery, Grant W., Lambrechts, Diether, Silva, Isabel dos Santos, Severi, Gianluca, Hamann, Ute, Pharoah, Paul, Easton, Douglas F., Chang-Claude, Jenny, Yannoukakos, Drakoulis, Nevanlinna, Heli, Wang, Xianshu and Couch, Fergus J. (2011) Common breast cancer susceptibility loci are associated with triple-negative breast cancer. Cancer Research, 71 19: 6240-6249. doi:10.1158/0008-5472.CAN-11-1266

Author Stevens, Kristen N.
Vachon, Celine M.
Lee, Adam M.
Slager, Susan
Lesnick, Timothy
Olswold, Curtis
Fasching, Peter A.
Miron, Penelope
Eccles, Diana
Carpenter, Jane E.
Godwin, Andrew K.
Ambrosone, Christine
Winqvist, Robert
Brauch, Hiltrud
Schmidt, Marjanka K.
Cox, Angela
Cross, Simon S.
Sawyer, Elinor
Hartmann, Arndt
Beckmann, Matthias W.
Schulz-Wendtland, Ruediger
Ekici, Arif B.
Tapper, William J.
Gerty, Susan M.
Durcan, Lorraine
Graham, Nikki
Hein, Rebecca
Nickels, Stephan
Flesch-Janys, Dieter
Heinz, Judith
Sinn, Hans-Peter
Konstantopoulou, Irene
Fostira, Florentia
Pectasides, Dimitrios
Dimopoulos, Athanasios M.
Fountzilas, George
Clarke, Christine L.
Balleine, Rosemary
Olson, Janet E.
Fredericksen, Zachary
Diasio, Robert B.
Pathak, Harsh
Ross, Eric
Weaver, JoEllen
Ruediger, Thomas
Forsti, Asta
Duennebier, Thomas
Ademuyiwa, Foluso
Kulkarni, Swati
Pylkaes, Katri
Jukkola-Vuorinen, Arja
Ko, Yon-Dschun
Van Limbergen, Erik
Janssen, Hilde
Peto, Julian
Fletcher, Olivia
Giles, Graham G.
Baglietto, Laura
Verhoef, Senno
Tomlinson, Ian
Kosma, Veli-Matti
Beesley, Jonathan
Greco, Dario
Blomqvist, Carl
Irwanto, Astrid
Liu, Jianjun
Blows, Fiona M.
Dawson, Sarah-Jane
Margolin, Sara
Mannermaa, Arto
Martin, Nicholas G.
Montgomery, Grant W.
Lambrechts, Diether
Silva, Isabel dos Santos
Severi, Gianluca
Hamann, Ute
Pharoah, Paul
Easton, Douglas F.
Chang-Claude, Jenny
Yannoukakos, Drakoulis
Nevanlinna, Heli
Wang, Xianshu
Couch, Fergus J.
Title Common breast cancer susceptibility loci are associated with triple-negative breast cancer
Journal name Cancer Research   Check publisher's open access policy
ISSN 0008-5472
Publication date 2011-10-01
Year available 2011
Sub-type Article (original research)
DOI 10.1158/0008-5472.CAN-11-1266
Open Access Status Not yet assessed
Volume 71
Issue 19
Start page 6240
End page 6249
Total pages 10
Place of publication Philadelphia, PA United States
Publisher American Association for Cancer Research
Language eng
Abstract Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six singlenucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.
Keyword Oncology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 70-2892-BR I
HR R_BG/04
P30 CA016056-32
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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