Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers

Hartz, Sarah M., Short, Susan E., Saccone, Nancy L., Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah H., Sun, Juzhong, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Geller, Frank, Guobjartsson, Daniel, Hansel, Nadia N., Jiang, Chenhui, Keskitalo-Vuokko, Kaisu, Liu, Zhen, Lyytikainen, Leo-Pekka, Michel, Martha, Rawal, Rajesh, Hum, Sc, Rosenberger, Albert, Scheet, Paul, Shaffer, John R., Teumer, Alexander, Thompson, John R., Vink, Jacqueline M., Vogelzangs, Nicole, Wenzlaff, Angela S., Wheeler, William, Xiao, Xiangjun, Yang, Bao-Zhu, Aggen, Steven H., Balmforth, Anthony J., Baumeister, Sebastian E., Beaty, Terri, Bennett, Siiri, Bergen, Andrew W., Boyd, Heather A., Broms, Ulla, Campbell, Harry, Chatterjee, Nilanjan, Chen, Jingchun, Cheng, Yu-Ching, Cichon, Sven, Couper, David, Cucca, Francesco, Dick, Danielle M., Foroud, Tatiana, Furberg, Helena, Giegling, Ina, Gu, Fangyi, Hall, Alistair S., Hallfors, Jenni, Han, Shizhong, Hartmann, Annette M., Hayward, Caroline, Heikkila, Kauko, Hewitt, John K., Hottenga, Jouke Jan, Jensen, Majken K., Jousilahti, Pekka, Kaakinen, Marika, Kittner, Steven J., Konte, Bettina, Korhonen, Tellervo, Landi, Maria-Teresa, Laatikainen, Tiina, Leppert, Mark, Levy, Steven M., Mathias, Rasika A., McNeil, Daniel W., Medland, Sarah E., Montgomery, Grant W., Muley, Thomas, Murray, Tanda, Nauck, Matthias, North, Kari, Pergadia, Michele, Polasek, Ozren, Ramos, Erin M., Ripatti, Samuli, Risch, Angela, Ruczinski, Ingo, Rudan, Igor, Salomaa, Veikko, Schlessinger, David, Styrkarsdottir, Unnur, Terracciano, Antonio, Uda, Manuela, Willemsen, Gonneke, Wu, Xifeng, Abecasis, Goncalo, Barnes, Kathleen, Bickeboeller, Heike, Boerwinkle, Eric, Boomsma, Dorret I., Caporaso, Neil, Duan, Jubao, Edenberg, Howard J., Francks, Clyde, Gejman, Pablo V., Gelernter, Joel, Grabe, Hans Joergen, Hops, Hyman, Jarvelin, Marjo-Riitta, Viikari, Jorma, Kahonen, Mika, Kendler, Kenneth S., Lehtimaki, Terho, Levinson, Douglas F., Marazita, Mary L., Marchini, Jonathan, Melbye, Mads, Mitchell, Braxton D., Murray, Jeffrey C., Nothen, Markus M., Penninx, Brenda W., Raitakari, Olli, Rietschel, Marcella, Rujescu, Dan, Samani, Nilesh J., Sanders, Alan R., Schwartz, Ann G., Shete, Sanjay, Shi, Jianxin, Spitz, Margaret, Stefansson, Kari, Swan, Gary E., Thorgeirsson, Thorgeir, Volzke, Henry, Wei, Qingyi, Wichmann, H. -Erich, Amos, Christopher I., Breslau, Naomi, Cannon, Dale S., Ehringer, Marissa, Grucza, Richard, Hatsukami, Dorothy, Heath, Andrew, Johnson, Eric O., Kaprio, Jaakko, Madden, Pamela, Martin, Nicholas G., Stevens, Victoria L., Stitzel, Jerry A., Weiss, Robert B., Kraft, Peter and Bierut, Laura J. (2012) Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Archives of General Psychiatry, 69 8: 854-861. doi:10.1001/archgenpsychiatry.2012.124


Author Hartz, Sarah M.
Short, Susan E.
Saccone, Nancy L.
Culverhouse, Robert
Chen, LiShiun
Schwantes-An, Tae-Hwi
Coon, Hilary
Han, Younghun
Stephens, Sarah H.
Sun, Juzhong
Chen, Xiangning
Ducci, Francesca
Dueker, Nicole
Franceschini, Nora
Frank, Josef
Geller, Frank
Guobjartsson, Daniel
Hansel, Nadia N.
Jiang, Chenhui
Keskitalo-Vuokko, Kaisu
Liu, Zhen
Lyytikainen, Leo-Pekka
Michel, Martha
Rawal, Rajesh
Hum, Sc
Rosenberger, Albert
Scheet, Paul
Shaffer, John R.
Teumer, Alexander
Thompson, John R.
Vink, Jacqueline M.
Vogelzangs, Nicole
Wenzlaff, Angela S.
Wheeler, William
Xiao, Xiangjun
Yang, Bao-Zhu
Aggen, Steven H.
Balmforth, Anthony J.
Baumeister, Sebastian E.
Beaty, Terri
Bennett, Siiri
Bergen, Andrew W.
Boyd, Heather A.
Broms, Ulla
Campbell, Harry
Chatterjee, Nilanjan
Chen, Jingchun
Cheng, Yu-Ching
Cichon, Sven
Couper, David
Cucca, Francesco
Dick, Danielle M.
Foroud, Tatiana
Furberg, Helena
Giegling, Ina
Gu, Fangyi
Hall, Alistair S.
Hallfors, Jenni
Han, Shizhong
Hartmann, Annette M.
Hayward, Caroline
Heikkila, Kauko
Hewitt, John K.
Hottenga, Jouke Jan
Jensen, Majken K.
Jousilahti, Pekka
Kaakinen, Marika
Kittner, Steven J.
Konte, Bettina
Korhonen, Tellervo
Landi, Maria-Teresa
Laatikainen, Tiina
Leppert, Mark
Levy, Steven M.
Mathias, Rasika A.
McNeil, Daniel W.
Medland, Sarah E.
Montgomery, Grant W.
Muley, Thomas
Murray, Tanda
Nauck, Matthias
North, Kari
Pergadia, Michele
Polasek, Ozren
Ramos, Erin M.
Ripatti, Samuli
Risch, Angela
Ruczinski, Ingo
Rudan, Igor
Salomaa, Veikko
Schlessinger, David
Styrkarsdottir, Unnur
Terracciano, Antonio
Uda, Manuela
Willemsen, Gonneke
Wu, Xifeng
Abecasis, Goncalo
Barnes, Kathleen
Bickeboeller, Heike
Boerwinkle, Eric
Boomsma, Dorret I.
Caporaso, Neil
Duan, Jubao
Edenberg, Howard J.
Francks, Clyde
Gejman, Pablo V.
Gelernter, Joel
Grabe, Hans Joergen
Hops, Hyman
Jarvelin, Marjo-Riitta
Viikari, Jorma
Kahonen, Mika
Kendler, Kenneth S.
Lehtimaki, Terho
Levinson, Douglas F.
Marazita, Mary L.
Marchini, Jonathan
Melbye, Mads
Mitchell, Braxton D.
Murray, Jeffrey C.
Nothen, Markus M.
Penninx, Brenda W.
Raitakari, Olli
Rietschel, Marcella
Rujescu, Dan
Samani, Nilesh J.
Sanders, Alan R.
Schwartz, Ann G.
Shete, Sanjay
Shi, Jianxin
Spitz, Margaret
Stefansson, Kari
Swan, Gary E.
Thorgeirsson, Thorgeir
Volzke, Henry
Wei, Qingyi
Wichmann, H. -Erich
Amos, Christopher I.
Breslau, Naomi
Cannon, Dale S.
Ehringer, Marissa
Grucza, Richard
Hatsukami, Dorothy
Heath, Andrew
Johnson, Eric O.
Kaprio, Jaakko
Madden, Pamela
Martin, Nicholas G.
Stevens, Victoria L.
Stitzel, Jerry A.
Weiss, Robert B.
Kraft, Peter
Bierut, Laura J.
Title Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
Formatted title
Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
Journal name Archives of General Psychiatry   Check publisher's open access policy
ISSN 0003-990X
Publication date 2012-08-01
Year available 2012
Sub-type Article (original research)
DOI 10.1001/archgenpsychiatry.2012.124
Open Access Status Not yet assessed
Volume 69
Issue 8
Start page 854
End page 861
Total pages 8
Place of publication Chicago, IL, United States
Publisher American Medical Association
Language eng
Abstract Context: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968.
Formatted abstract
Context: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968.
Objective: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking.
Data Sources:
Primary data.
Study Selection: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy.
Data Extraction: Uniform statistical analysis scripts were runlocally. Startingwith94 050ever-smokersfrom43studies, we extracted the heavy smokers (CPD>20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33 348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavyvs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum.
Data Synthesis: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR]=1.45; 95% CI, 1.36-1.55; n=13 843) than were carriers of the risk allele who were late-onset smokers (OR=1.27; 95% CI, 1.21-1.33, n=19 505) (P=.01).
Conclusion: These results highlight an increased genetic vulnerability to smoking in early-onset smokers.
Keyword Psychiatry
Psychiatry
PSYCHIATRY, SCI
PSYCHIATRY, SSCI
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01HL089651-01
7PT2000-2004
104781
LSHM-CT-2004-005166
129494
01ZZ9603
01GS08144
10-000-1002
GR 1912/5-1
R01 AA11330
NIHDA12854
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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