Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Anderson, Carl A., Boucher, Gabrielle, Lees, Charlie W., Franke, Andre, D'Amato, Mauro, Taylor, Kent D., Lee, James C., Goyette, Philippe, Imielinski, Marcin, Latiano, Anna, Lagace, Caroline, Scott, Regan, Amininejad, Leila, Bumpstead, Suzannah, Baidoo, Leonard, Baldassano, Robert N., Barclay, Murray, Bayless, Theodore M., Brand, Stephan, Buening, Carsten, Colombel, Jean-Frederic, Denson, Lee A., De Vos, Martine, Dubinsky, Marla, Edwards, Cathryn, Ellinghaus, David, Fehrmann, Rudolf S. N., Floyd, James A. B., Florin, Timothy, Franchimont, Denis, Franke, Lude, Georges, Michel, Glas, Juergen, Glazer, Nicole L., Guthery, Stephen L., Haritunians, Talin, Hayward, Nicholas K., Hugot, Jean-Pierre, Jobin, Gilles, Laukens, Debby, Lawrance, Ian, Lemann, Marc, Levine, Arie, Libioulle, Cecile, Louis, Edouard, McGovern, Dermot P., Milla, Monica, Montgomery, Grant W., Morley, Katherine I., Mowat, Craig, Ng, Aylwin, Newman, William, Ophoff, Roel A., Papi, Laura, Palmieri, Orazio, Peyrin-Biroulet, Laurent, Panes, Julian, Phillips, Anne, Prescott, Natalie J., Proctor, Deborah D., Roberts, Rebecca, Russell, Richard, Rutgeerts, Paul, Sanderson, Jeremy, Sans, Miquel, Schumm, Philip, Seibold, Frank, Sharma, Yashoda, Simms, Lisa A., Seielstad, Mark, Steinhart, A. Hillary, Targan, Stephan R., van den Berg, Leonard H., Vatn, Morten, Verspaget, Hein, Walters, Thomas, Wijmenga, Cisca, Wilson, David C., Westra, Harm-Jan, Xavier, Ramnik J., Zhao, Zhen Z., Ponsioen, Cyriel Y., Andersen, Vibeke, Torkvist, Leif, Gazouli, Maria, Anagnou, Nicholas P., Karlsen, Tom H., Kupcinskas, Limas, Sventoraityte, Jurgita, Mansfield, John C., Kugathasan, Subra, Silverberg, Mark S., Halfvarson, Jonas, Rotter, Jerome I., Mathew, Christopher G., Griffiths, Anne M., Gearry, Richard, Ahmad, Tariq, Brant, Steven R., Chamaillard, Mathias, Satsangi, Jack, Cho, Judy H., Schreiber, Stefan, Daly, Mark J., Barrett, Jeffrey C., Parkes, Miles, Annese, Vito, Hakonarson, Hakon, Radford-Smith, Graham, Duerr, Richard H., Vermeire, Severine, Weersma, Rinse K. and Rioux, John D. (2011) Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature Genetics, 43 3: 246-252. doi:10.1038/ng.764


Author Anderson, Carl A.
Boucher, Gabrielle
Lees, Charlie W.
Franke, Andre
D'Amato, Mauro
Taylor, Kent D.
Lee, James C.
Goyette, Philippe
Imielinski, Marcin
Latiano, Anna
Lagace, Caroline
Scott, Regan
Amininejad, Leila
Bumpstead, Suzannah
Baidoo, Leonard
Baldassano, Robert N.
Barclay, Murray
Bayless, Theodore M.
Brand, Stephan
Buening, Carsten
Colombel, Jean-Frederic
Denson, Lee A.
De Vos, Martine
Dubinsky, Marla
Edwards, Cathryn
Ellinghaus, David
Fehrmann, Rudolf S. N.
Floyd, James A. B.
Florin, Timothy
Franchimont, Denis
Franke, Lude
Georges, Michel
Glas, Juergen
Glazer, Nicole L.
Guthery, Stephen L.
Haritunians, Talin
Hayward, Nicholas K.
Hugot, Jean-Pierre
Jobin, Gilles
Laukens, Debby
Lawrance, Ian
Lemann, Marc
Levine, Arie
Libioulle, Cecile
Louis, Edouard
McGovern, Dermot P.
Milla, Monica
Montgomery, Grant W.
Morley, Katherine I.
Mowat, Craig
Ng, Aylwin
Newman, William
Ophoff, Roel A.
Papi, Laura
Palmieri, Orazio
Peyrin-Biroulet, Laurent
Panes, Julian
Phillips, Anne
Prescott, Natalie J.
Proctor, Deborah D.
Roberts, Rebecca
Russell, Richard
Rutgeerts, Paul
Sanderson, Jeremy
Sans, Miquel
Schumm, Philip
Seibold, Frank
Sharma, Yashoda
Simms, Lisa A.
Seielstad, Mark
Steinhart, A. Hillary
Targan, Stephan R.
van den Berg, Leonard H.
Vatn, Morten
Verspaget, Hein
Walters, Thomas
Wijmenga, Cisca
Wilson, David C.
Westra, Harm-Jan
Xavier, Ramnik J.
Zhao, Zhen Z.
Ponsioen, Cyriel Y.
Andersen, Vibeke
Torkvist, Leif
Gazouli, Maria
Anagnou, Nicholas P.
Karlsen, Tom H.
Kupcinskas, Limas
Sventoraityte, Jurgita
Mansfield, John C.
Kugathasan, Subra
Silverberg, Mark S.
Halfvarson, Jonas
Rotter, Jerome I.
Mathew, Christopher G.
Griffiths, Anne M.
Gearry, Richard
Ahmad, Tariq
Brant, Steven R.
Chamaillard, Mathias
Satsangi, Jack
Cho, Judy H.
Schreiber, Stefan
Daly, Mark J.
Barrett, Jeffrey C.
Parkes, Miles
Annese, Vito
Hakonarson, Hakon
Radford-Smith, Graham
Duerr, Richard H.
Vermeire, Severine
Weersma, Rinse K.
Rioux, John D.
Title Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2011-03-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/ng.764
Open Access Status Not yet assessed
Volume 43
Issue 3
Start page 246
End page 252
Total pages 7
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Abstract Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.
Formatted abstract
Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10-8), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.
Keyword Genetics & Heredity
Genetics & Heredity
GENETICS & HEREDITY
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 083948/Z/07/Z
DK064869
M01-RR00425
P01-DK046763
BR 1912/5-1
P50/05/EKMS05/62
90.700.281
BSIK03009
93519031
916.10.135
DK062431
DK062422
DK062420
DK062432
DK062423
DK062413
DK076984
DK084554
DK062429
DK069513
DK83756
AI062773
DK043351
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
 
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