A METHOD OF DETERMINING INTRINSIC HEPATIC CLEARANCE FROM THE FIRST‐PASS EFFECT

Bass L. and Winkler K. (1980) A METHOD OF DETERMINING INTRINSIC HEPATIC CLEARANCE FROM THE FIRST‐PASS EFFECT. Clinical and Experimental Pharmacology and Physiology, 7 3: 339-343. doi:10.1111/j.1440-1681.1980.tb00080.x


Author Bass L.
Winkler K.
Title A METHOD OF DETERMINING INTRINSIC HEPATIC CLEARANCE FROM THE FIRST‐PASS EFFECT
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 1440-1681
Publication date 1980-01-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.1980.tb00080.x
Open Access Status Not yet assessed
Volume 7
Issue 3
Start page 339
End page 343
Total pages 5
Subject 1314 Physiology
3004 Pharmacology
2737 Physiology (medical)
Abstract 1. The relation between systemic hepatic clearance, intrinsic hepatic clearance and hepatic blood flow is considered from the point of view of the sinusoidal perfusion (parallel tube) model of the liver. 2. It is shown how intrinsic hepatic clearance may be calculated, for substrates eliminated in the liver and the kidney only, from data obtained by introducing successively an oral and an intravenous dose (i.e., by using the first‐pass effect) without the clinically cumbersome catheterization of the liver vein. 3. The rate of hepatic blood flow is shown to follow from the same data. Copyright
Keyword clearance
hepatic blood flow
kinetics
liver function
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 30 Aug 2016, 14:26:50 EST by System User