Dallemagne C., Cross R.B., Law S., Verschuer L., Wholohan T. and Yesberg N.E. (1986) HYPOTENSION‐INDUCED HYPOKALAEMIA IN SHEEP. Quarterly Journal of Experimental Physiology, 71 4: 569-575. doi:10.1113/expphysiol.1986.sp003017

Author Dallemagne C.
Cross R.B.
Law S.
Verschuer L.
Wholohan T.
Yesberg N.E.
Journal name Quarterly Journal of Experimental Physiology   Check publisher's open access policy
ISSN 1469-445X
Publication date 1986-10-10
Sub-type Article (original research)
DOI 10.1113/expphysiol.1986.sp003017
Volume 71
Issue 4
Start page 569
End page 575
Total pages 7
Subject 1314 Physiology
Abstract Plasma K+ was measured in Merino ewes during 50‐90 min periods of hypotension induced by sodium nitroprusside, isoprenaline, verapamil or nifedipine. Doses were adjusted to produce falls in systemic blood pressure of approximately 20 mmHg. All of these drugs caused decreases in plasma K+ which could not be attributed to increased urinary excretion of K+. In all cases plasma renin activity increased during the hypotension. Plasma aldosterone concentration which was measured in some sodium nitroprusside experiments also increased during the hypotension. However, enhancement of the plasma renin activity and plasma aldosterone concentration responses by prior sodium depletion of the sheep by furosemide administration or suppression of the plasma renin activity and plasma aldosterone concentration responses by prior salt loading did not influence the magnitude of the hypotension‐induced hypokalaemia.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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