Binding of the immunosuppressant peptide cyclosporine a to calcium, zinc and copper. Is cyclosporine a an ionophore?

Dancer R.J. and Jones A. (1995) Binding of the immunosuppressant peptide cyclosporine a to calcium, zinc and copper. Is cyclosporine a an ionophore?. Australian Journal of Chemistry, 48 11: 1835-1841. doi:10.1071/CH9951835


Author Dancer R.J.
Jones A.
Title Binding of the immunosuppressant peptide cyclosporine a to calcium, zinc and copper. Is cyclosporine a an ionophore?
Journal name Australian Journal of Chemistry   Check publisher's open access policy
ISSN 1445-0038
Publication date 1995-01-01
Year available 1995
Sub-type Article (original research)
DOI 10.1071/CH9951835
Open Access Status Not yet assessed
Volume 48
Issue 11
Start page 1835
End page 1841
Total pages 7
Place of publication COLLINGWOOD
Publisher C S I R O PUBLICATIONS
Language eng
Subject 1600 Chemistry
Abstract Cyclosporin A is an immunosuppressant drug that has made organ transplantation possible during the past decade.This conformationally flexible peptide, which interferes in an unknown way with calcium-dependent intracellular signalling events, has now been examined in aqueous and acetone solutions containing metal ions. By using electrospray mass spectrometry and nuclear magnetic resonance spectroscopy, cyclosporin A was found to bind directly to endogenous metal ions Ca2+, Zn2+and Cu2+, with the highest affinity being for Ca2+.These observations raise the possibility that cyclosporins might directly regulate local concentrations of metal ions associated with intracellular signal transduction. This may beanimportant clue to the mechanism of immunoregulation by this and structurally related drugs.
Keyword Chemistry, Multidisciplinary
Chemistry
CHEMISTRY, MULTIDISCIPLINARY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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