Solasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies

Cham B.E. (1994) Solasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies. Asia Pacific Journal of Pharmacology, 9 2: 113-118.

Author Cham B.E.
Title Solasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies
Journal name Asia Pacific Journal of Pharmacology   Check publisher's open access policy
ISSN 0217-9687
Publication date 1994-01-01
Sub-type Critical review of research, literature review, critical commentary
Open Access Status Not yet assessed
Volume 9
Issue 2
Start page 113
End page 118
Total pages 6
Subject 3004 Pharmacology
Abstract Solamargine [(22R,25R)-spiro-5-en-3 beta-yl-alpha-L-rhamnopyranosyl- (1----2glu)-O-alpha-L-rhamnopyranozyl (1----4glu)-beta-D-glucopyranoze], a glycoside of solasodine preferentially inhibits the uptake of tritiated thymidine by cancer cells. In contrast, solamargine at equivalent concentration, and the mono- and diglycosides of solasodine have a limited effect on the uptake of tritiated thymidine for other cell types, including unstimulated lymphocytes and lymphocytes stimulated with Con A. In contrast the solasodine glycosides do not inhibit the uptake of tritiated thymidine by lymphocytes stimulated with PHA or PWM. The inhibition of tritiated thymidine uptake by solamargine and the mono- and di-glycosides of solasodine are dependent upon their cellular uptake by endogenous endocytic lectins (EELs). The mode of action of the solasodine glycosides, in particular solamargine, appears to be the induction of cell lysis, as determined by morphological examination.
Keyword anti-cancer
endocytic endogenous lectins
receptor
solasodine glycosides
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import - Archived
 
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