Enhanced drug metabolism in cigarette smokers

Hart P., Farrell G.C., Cooksley W.G.E. and Powell L.W. (1976) Enhanced drug metabolism in cigarette smokers. British Medical Journal, 2 6028: 147-149. doi:10.1136/bmj.2.6028.147


Author Hart P.
Farrell G.C.
Cooksley W.G.E.
Powell L.W.
Title Enhanced drug metabolism in cigarette smokers
Journal name British Medical Journal   Check publisher's open access policy
ISSN 0007-1447
Publication date 1976-01-01
Sub-type Article (original research)
DOI 10.1136/bmj.2.6028.147
Open Access Status Not yet assessed
Volume 2
Issue 6028
Start page 147
End page 149
Total pages 3
Subject 2700 Medicine
Abstract The effect of cigarette smoking on salivary antipyrine disappearance rate, and as an index of hepatic drug metabolism, was studied in 42 healthy subjects. Antipyrine half life was significantly shorter in smokers compared with non-smokers. To determine whether this difference was due solely to tobacco consumption eight subjects were restudied two months after they stopped smoking. The mean antipyrine disappearance rate in this group increased by 23% in contrast to that of a control group, which did not alter. Cigarette smoking contributes to the considerable variation in interindividual rates of drug metabolism.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 30 Aug 2016, 12:46:40 EST by System User