THE EFFECTS OF SAR1ALA8‐ANGIOTENSIN II IN VASOPRESSIN‐TREATED DEHYDRATED SHEEP

Kelly C., Wholohan T. and Yesberg N.E. (1983) THE EFFECTS OF SAR1ALA8‐ANGIOTENSIN II IN VASOPRESSIN‐TREATED DEHYDRATED SHEEP. Quarterly Journal of Experimental Physiology, 68 2: 161-166. doi:10.1113/expphysiol.1983.sp002708


Author Kelly C.
Wholohan T.
Yesberg N.E.
Title THE EFFECTS OF SAR1ALA8‐ANGIOTENSIN II IN VASOPRESSIN‐TREATED DEHYDRATED SHEEP
Journal name Quarterly Journal of Experimental Physiology   Check publisher's open access policy
ISSN 1469-445X
Publication date 1983-04-07
Sub-type Article (original research)
DOI 10.1113/expphysiol.1983.sp002708
Volume 68
Issue 2
Start page 161
End page 166
Total pages 6
Subject 1314 Physiology
Abstract Mildly dehydrated conscious Merino ewes were infused with vasopressin (AVP) at 5 mu.min−1 alone and simultaneously with the angiotensin II receptor blocker sar1ala8‐angiotensin II (saralasin) at 15 µg.min−1. AVP was slightly pressor and produced an increase in the calculated total peripheral resistance, and an increase in glomerular filtration rate, urine flow and electrolyte excretion, without a change in total renal plasma flow. These results indicate renal efferent arteriolar vasoconstriction as well as other non‐renal vasoconstriction. Saralasin infusion checked the rise in total peripheral resistance (which continued to increase after saralasin withdrawal), but caused a marked increase in renal vascular resistance resulting in a decrease in renal plasma flow and to a lesser extent in glomerular filtration rate. These results suggest that saralasin was acting as an angiotensin II agonist in the kidney, but as an antagonist elsewhere. Deductions from previous experiments in the literature of the renal function of angiotensin II, based on its supposed inhibition by saralasin, may not be justified.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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