Effect of a smooth muscle relaxant from the stonefish, Synanceia trachynis, on KCl-induced responses in the guinea-pig vas deferens

Wong Hoy A.W. and Cameron A.M. (1986) Effect of a smooth muscle relaxant from the stonefish, Synanceia trachynis, on KCl-induced responses in the guinea-pig vas deferens. European Journal of Pharmacology, 129 1-2: 105-112. doi:10.1016/0014-2999(86)90341-9


Author Wong Hoy A.W.
Cameron A.M.
Title Effect of a smooth muscle relaxant from the stonefish, Synanceia trachynis, on KCl-induced responses in the guinea-pig vas deferens
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 1986-09-23
Sub-type Article (original research)
DOI 10.1016/0014-2999(86)90341-9
Volume 129
Issue 1-2
Start page 105
End page 112
Total pages 8
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
Abstract Stonefish skin secretion contains a smooth muscle relaxant, synancein II, that selectively inhibits tonic responses of KCl-induced contractions of the guinea-pig vas deferens. Synancein II (5-50 μg/ml) and nifedipine (10-8-10-7 M) reduced tonic responses equaly. Over these concentrations, synancein II inhibited phasic responses more than did nifedipine. Rapid inhibition of phasic responses by synancein II (low concentrations) but its inability to block this response at high concentrations suggests that more than one extracellular and/or intracellular Ca2+ source may contribute to the generation of the phasic response. Some calcium antagonists selectively inhibit tonic responses induced by KCl in many different organs, whilst others inhibit phasic responses. Whereas we previously reported that synancein II selectively inhibits phasic rather than tonic responses in the guinea-pig ileum, the present result reveals a reversal of this selectivity.
Keyword (Stonefish, Synanceia trachynis)
Calcium antagonist
KCl-induced contraction
Nifedipine
Organ selectivity
Smooth muscle
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 30 Aug 2016, 11:59:45 EST by System User