Cell-mediated immunity and specific serum factors in human cancer: The leukocyte adherence inhibition test

Maluish A. and Halliday W.J. (1974) Cell-mediated immunity and specific serum factors in human cancer: The leukocyte adherence inhibition test. Journal of the National Cancer Institute, 52 5: 1415-1420. doi:10.1093/jnci/52.5.1415


Author Maluish A.
Halliday W.J.
Title Cell-mediated immunity and specific serum factors in human cancer: The leukocyte adherence inhibition test
Journal name Journal of the National Cancer Institute   Check publisher's open access policy
ISSN 1460-2105
Publication date 1974-01-01
Sub-type Article (original research)
DOI 10.1093/jnci/52.5.1415
Volume 52
Issue 5
Start page 1415
End page 1420
Total pages 6
Subject 1306 Cancer Research
2730 Oncology
Abstract Blood leukocytes from patients with cancer (malignant melanoma; adenocarcinoma of colon, rectum, and breast) reacted with aqueous extracts of tumors of the corresponding type, with the result that adherence of the leu kocytes to glass was diminished. Leukocytes from normal individuals did not react. The leukocyte adherence inhibition (LAI) test could be completed in a few hours. Sera from tumor-bearing patients blocked the LAI reaction of their own leukocytes or leukocytes from other patients with the same type of tumor. Serum blocking activity was lost soon after surgical removal of the tumor; the patient’s serum then became unblocking. The LAI technique gave consistent results in a series of patients, analogous to those reported with the lymphocyte cytotoxicity test, and was easier and quicker.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 30 Aug 2016, 11:57:51 EST by System User