Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent

Wanstall J.C. and O'Donnell S.R. (1989) Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent. European Journal of Pharmacology, 159 3: 241-246. doi:10.1016/0014-2999(89)90154-4

Author Wanstall J.C.
O'Donnell S.R.
Title Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 1989-01-17
Sub-type Article (original research)
DOI 10.1016/0014-2999(89)90154-4
Volume 159
Issue 3
Start page 241
End page 246
Total pages 6
Language eng
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
Abstract On rat aorta, diltiazem (0.2 μM) caused parallel shifts in the Ca2+ concentration-response curves (K+-depolarized preparations). In aged (> 19 months) rats, this shift (0.57 log units) was smaller than in young (2 months) rats (1.04 log units) indicating an age-related reduction in the potency of diltiazem. Felodipine (10 nM), like diltiazem (1 μM) in a previous study, depressed the maximum response to noradrenaline more in preparations from aged rats (40% reduction) than from young rats (14% reduction). This increase in the effect of felodipine or diltiazem vs. noradrenaline reflected a reduction in the α-adrenoceptor reserve for noradrenaline. Accordingly, the depression in the maximum responses to other spasmogens (5-HT or K+) by 1 μM diltiazem was not increased by age (5-HT, young 59%, aged 49% reduction; K+, young 65%, aged 70% reduction). Thus aging can have two opposing influences on the effects of Ca2+ entry blocking drugs on rat aorta - a decrease in potency, yet an increase in effectiveness against spasmogens with a reduced receptor reserve.
Keyword Aging
Aorta (rat)
Ca2+ entry blocking drugs
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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