Ultrastructure of the tibial epiphyseal growth plate in microphthalmic (mi/mi) mice

Paxinos-Maroudas D., Powell R.N. and Newcomb G.M. (1989) Ultrastructure of the tibial epiphyseal growth plate in microphthalmic (mi/mi) mice. Archives of Oral Biology, 34 2: 77-84. doi:10.1016/0003-9969(89)90129-5


Author Paxinos-Maroudas D.
Powell R.N.
Newcomb G.M.
Title Ultrastructure of the tibial epiphyseal growth plate in microphthalmic (mi/mi) mice
Journal name Archives of Oral Biology   Check publisher's open access policy
ISSN 0003-9969
Publication date 1989-01-01
Sub-type Article (original research)
DOI 10.1016/0003-9969(89)90129-5
Volume 34
Issue 2
Start page 77
End page 84
Total pages 8
Subject 3500 Dentistry
Abstract Osteoclasts from growth plates of affected (mi/mi) and control (mi/+) microphthalmic mice, from newborn to 15 days old, were examined. Osteoclasts from unaffected mice were generally large, multinucleated cells with distinct ruffled borders and clear zones. Osteoclasts from the mi/mi litter mates were predominantly mononucleated, lacking in ruffled borders, clear zones and an abundance of organelles, features not normally associated with a functioning resorptive cell. The lamina limitans was more distinct in mi/mi mice. By 15 days, no evidence of bone resorption was seen in mi/mi mice. The immature appearance of osteoclasts and the lack of bone marrow cavity formation in mi/mi mice may result from either a fusion defect or from a limited life span of osteoclasts.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 30 Aug 2016, 11:48:58 EST by System User