Co-localization of GABA- and tyrosine hydroxylase-like immunoreactivities in amacrine cells of the rabbit retina

Young H.M. (1994) Co-localization of GABA- and tyrosine hydroxylase-like immunoreactivities in amacrine cells of the rabbit retina. Vision Research, 34 8: 995-999. doi:10.1016/0042-6989(94)90003-5


Author Young H.M.
Title Co-localization of GABA- and tyrosine hydroxylase-like immunoreactivities in amacrine cells of the rabbit retina
Journal name Vision Research   Check publisher's open access policy
ISSN 0042-6989
Publication date 1994-01-01
Sub-type Article (original research)
DOI 10.1016/0042-6989(94)90003-5
Open Access Status Not yet assessed
Volume 34
Issue 8
Start page 995
End page 999
Total pages 5
Subject 2731 Ophthalmology
2809 Sensory Systems
Abstract Previous studies have shown that many of the tyrosine hydroxylase-immunoreactive (TH-IR) amacrine cells in the retina of mammals also show GABA-like immunoreactivity (GABA-IR). However such co-localization has yet to be demonstrated in the rabbit retina. In this study the proportion of TH-IR amacrine cells that show GABA-IR has been determined in the retina of the cat, rat and rabbit following fixation with 4% paraformaldehyde plus varying concentrations of glutaraldehyde. In the retina of the cat and rat, most of the TH-IR amacrine cells showed GABA-IR following fixation using low concentrations (0.01 or 0.1%) of glutaraldehyde. However in the rabbit retina very few of the TH-IR amacrine cells showed GABA-IR unless the glutaraldehyde concentration in the fixative was 0.5% or greater. The results suggest that the dopaminergic amacrine cells in the rabbit retina contain only very low levels of GABA, which are close to the detection limit of the antibody.
Keyword Amacrine cells
Co-localization
Dopamine
GABA
Rabbit
Retina
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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