Comparison of fracture rates between indigenous and non-indigenous populations: a systematic review protocol

Brennan-Olsen, Sharon L., Quirk, Shae E., Leslie, William D., Toombs, Maree, Holloway, Kara L., Hosking, Sarah M., Pasco, Julie A., Doolan, Brianna J., Page, Richard S. and Williams, Lana J. (2016) Comparison of fracture rates between indigenous and non-indigenous populations: a systematic review protocol. BMJ Open, 6 8: e012124.1-e012124.6. doi:10.1136/bmjopen-2016-012124


Author Brennan-Olsen, Sharon L.
Quirk, Shae E.
Leslie, William D.
Toombs, Maree
Holloway, Kara L.
Hosking, Sarah M.
Pasco, Julie A.
Doolan, Brianna J.
Page, Richard S.
Williams, Lana J.
Title Comparison of fracture rates between indigenous and non-indigenous populations: a systematic review protocol
Journal name BMJ Open   Check publisher's open access policy
ISSN 2044-6055
Publication date 2016-08-26
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1136/bmjopen-2016-012124
Open Access Status DOI
Volume 6
Issue 8
Start page e012124.1
End page e012124.6
Total pages 6
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Subject 2700 Medicine
Abstract INTRODUCTION: Over recent years, there has been concerted effort to 'close the gap' in the disproportionately reduced life expectancy and increased morbidity experienced by indigenous compared to non-indigenous persons. Specific to musculoskeletal health, some data suggest that indigenous peoples have a higher risk of sustaining a fracture compared to non-indigenous peoples. This creates an imperative to identify factors that could explain differences in fracture rates. This protocol presents our aim to conduct a systematic review, first, to determine whether differences in fracture rates exist for indigenous versus non-indigenous persons and, second, to identify any risk factors that might explain these differences.
Formatted abstract
Introduction: Over recent years, there has been concerted effort to ‘close the gap’ in the disproportionately reduced life expectancy and increased morbidity experienced by indigenous compared to non-indigenous persons. Specific to musculoskeletal health, some data suggest that indigenous peoples have a higher risk of sustaining a fracture compared to non-indigenous peoples. This creates an imperative to identify factors that could explain differences in fracture rates. This protocol presents our aim to conduct a systematic review, first, to determine whether differences in fracture rates exist for indigenous versus non-indigenous persons and, second, to identify any risk factors that might explain these differences.

Methods and analysis:
We will conduct a systematic search of PubMed, OVID, MEDLINE, CINAHL and EMBASE to identify articles that compare all-cause fracture rates at any skeletal site between indigenous and non-indigenous persons of any age. Eligibility of studies will be determined by 2 independent reviewers. Studies will be assessed for methodological quality using a previously published process. We will conduct a meta-analysis and use established statistical methods to identify and control for heterogeneity where appropriate. Should heterogeneity prevents numerical syntheses, we will undertake a best-evidence analysis to determine the level of evidence for differences in fracture between indigenous and non-indigenous persons.

Ethics and dissemination:
This systematic review will use published data; thus, ethical permissions are not required. In addition to peer-reviewed publication, findings will be presented at (inter)national conferences, disseminated electronically and in print, and will be made available to key country-specific decision-makers with authority for indigenous health.
Keyword Medicine, General & Internal
General & Internal Medicine
Q-Index Code CX
Q-Index Status Provisional Code
Grant ID 1107510
1064272
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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Created: Sun, 28 Aug 2016, 23:20:46 EST by Mrs Maree Toombs on behalf of Rural Clinical School