Cholesterol synthesis and hmg coa reductase activity during hepatocarcinogenesis in rats

Gregg R.G., Davidson M. and Wilce P.A. (1986) Cholesterol synthesis and hmg coa reductase activity during hepatocarcinogenesis in rats. International Journal of Biochemistry, 18 4: 389-393. doi:10.1016/0020-711X(86)90046-7


Author Gregg R.G.
Davidson M.
Wilce P.A.
Title Cholesterol synthesis and hmg coa reductase activity during hepatocarcinogenesis in rats
Journal name International Journal of Biochemistry   Check publisher's open access policy
ISSN 0020-711X
Publication date 1986-01-01
Sub-type Article (original research)
DOI 10.1016/0020-711X(86)90046-7
Volume 18
Issue 4
Start page 389
End page 393
Total pages 5
Subject 1303 Specialist Studies in Education
Abstract 1. 1. Two treatment regimes were used to produce preneoplastic foci (as determined by the presence of γ-glutamyl transferase) in rat liver. 2. 2. Increased [14C]acetate incorporation into cholesterol and 3-hydroxy-3-methyl glutaryl CoA reductase activity were associated with high levels of γ-glutamyl transpeptidase and foci formation. 3. 3. Dietary feedback inhibition of both[14C]acetate incorporation and 3-hydroxy-3-methyl glutaryl CoA reductase activity was reduced at a selected time when γ-glutamyl transpeptidase activity was high. 4. 4. These changes could not be accounted for by a regenerative response in the liver.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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