CONVERTING‐ENZYME INHIBITION AND 1‐SARCOSINE‐8‐ISOLEUCINE‐ANGIOTENSIN II: EFFECTS ON RENAL FUNCTION IN THE DEHYDRATED SHEEP

Yesberg N.E., Henderson M., Dallemagne C., Law S., Hamilton D. and Cross R.B. (1984) CONVERTING‐ENZYME INHIBITION AND 1‐SARCOSINE‐8‐ISOLEUCINE‐ANGIOTENSIN II: EFFECTS ON RENAL FUNCTION IN THE DEHYDRATED SHEEP. Quarterly Journal of Experimental Physiology, 69 1: 133-143. doi:10.1113/expphysiol.1984.sp002774


Author Yesberg N.E.
Henderson M.
Dallemagne C.
Law S.
Hamilton D.
Cross R.B.
Title CONVERTING‐ENZYME INHIBITION AND 1‐SARCOSINE‐8‐ISOLEUCINE‐ANGIOTENSIN II: EFFECTS ON RENAL FUNCTION IN THE DEHYDRATED SHEEP
Journal name Quarterly Journal of Experimental Physiology   Check publisher's open access policy
ISSN 1469-445X
Publication date 1984-01-22
Sub-type Article (original research)
DOI 10.1113/expphysiol.1984.sp002774
Open Access Status Not yet assessed
Volume 69
Issue 1
Start page 133
End page 143
Total pages 11
Subject 1314 Physiology
Abstract The effect of a converting‐enzyme inhibitor (captopril) was studied in nine conscious dehydrated Merino ewes. Captopril (4 mg I.V. over 40 min) caused significant decreases in mean arterial blood pressure (M.A.B.P.), renal vascular resistance (R.V.R.) and filtration fraction, and increases in urine flow (V), sodium excretion, glomerular filtration rate (G.F.R.), renal plasma flow, solute clearance (Cosm), solute‐free water reabsorption (TC,H2O) and plasma renin activity (P.R.A.). None of these effects was observed when captopril was similarly administered to sheep pretreated with angiotensin II (AII) receptor blocker, l‐sarcosine‐8‐isoleucine‐AII (sarileucin). It is concluded that the effects of captopril were probably not due to bradykinin potentiation but rather to decreased levels of circulating AII. The effect of sarileucin itself was complex. It effectively blocked the pressor response to administered AII, but it also had an AII‐like effect indicated by a rise in R.V.R., and decreases in V, G.F.R., Cosm and TC,H2O. This apparent mixture of All agonist and antagonist properties probably accounts for the absence of any change in M.A.B.P. or P.R.A. during sarileucin administration.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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