Apoptosis in the anterior pituitary gland of the rat: Studies with estrogen and bromocriptine

Drewett N., Jacobi J.M., Willgoss D.A. and Lloyd H.M. (1993) Apoptosis in the anterior pituitary gland of the rat: Studies with estrogen and bromocriptine. Neuroendocrinology, 57 1: 89-95. doi:10.1159/000126346


Author Drewett N.
Jacobi J.M.
Willgoss D.A.
Lloyd H.M.
Title Apoptosis in the anterior pituitary gland of the rat: Studies with estrogen and bromocriptine
Journal name Neuroendocrinology   Check publisher's open access policy
ISSN 1423-0194
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1159/000126346
Volume 57
Issue 1
Start page 89
End page 95
Total pages 7
Subject 1310 Endocrinology
2712 Endocrinology, Diabetes and Metabolism
2804 Cellular and Molecular Neuroscience
2807 Endocrine and Autonomic Systems
2800 Neuroscience
Abstract Apoptosis was investigated by electron and light microscopy in the anterior pituitary gland of the male Fischer rat in which hyperplasia of prolactin-secreting cells had been induced by estrogen implanted subcutaneously for 6 weeks. Counts by light microscopy of apoptotic cells and cells containing pha- gocytosed apoptotic bodies increased during a period of 44 h after estrogen withdrawal. Necrosis was present but was not prominent. Administration of bromocriptine after estrogen withdrawal increased apoptotic counts to nearly double those in the absence of bromocriptine. Bromocriptine caused some increase in necrosis. Apoptosis occurred in prolactin-secreting cells identified by immunostaining and in other cells. Phagocytosed apoptotic bodies were seen in folliculo-stellate and not in other cells. It is concluded that apoptosis occurs in the anterior pituitary gland and is induced by bromocriptine. Phagocytosis of apoptotic bodies is a function of the folliculo-stellate cells.
Keyword Apoptosis
Bromocriptine
Estrogen
Folliculo-stellate cells
Pituitary
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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