Bile canalicular injury in lantana poisoning

Pass M.A. and Goosem M.W. (1983) Bile canalicular injury in lantana poisoning. Toxicon, 21 SUPPL. 3: 337-340. doi:10.1016/0041-0101(83)90224-6


Author Pass M.A.
Goosem M.W.
Title Bile canalicular injury in lantana poisoning
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 1983-01-01
Sub-type Article (original research)
DOI 10.1016/0041-0101(83)90224-6
Volume 21
Issue SUPPL. 3
Start page 337
End page 340
Total pages 4
Subject 3005 Toxicology
Abstract Intrahepatic cholestasis associated with bile canalicular injury occurred when the plant Lantana camara was administered orally to sheep and when female rats were dosed orally with the toxic lantana triterpene reduced lantadene A. When reduced lantadene A was given into the portal vein of a sheep, 85% was excreted in bile during the following week. Bile canalicular membrane fractions prepared from intoxicated rats contained metabolites of reduced lantadene A and 13C NMR spectra of these fractions showed changes compatible with disorganisation of the phospholipids in the membranes. It is concluded that lantana toxins are excreted in bile and cholestasis may result from an interaction of triterpene metabolites with components of the bile canalicular membranes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 23 Aug 2016, 13:59:38 EST by System User