Regulation of cell-mediated immunologic reactivity to moloney murine sarcoma virus-induced tumors. I. cell and serum activity detected by leukocyte adherence inhibition

Koppl T.A. and Halliday W.J. (1981) Regulation of cell-mediated immunologic reactivity to moloney murine sarcoma virus-induced tumors. I. cell and serum activity detected by leukocyte adherence inhibition. Journal of the National Cancer Institute, 66 6: 1089-1096. doi:10.1093/jnci/66.6.1089


Author Koppl T.A.
Halliday W.J.
Title Regulation of cell-mediated immunologic reactivity to moloney murine sarcoma virus-induced tumors. I. cell and serum activity detected by leukocyte adherence inhibition
Journal name Journal of the National Cancer Institute   Check publisher's open access policy
ISSN 1460-2105
Publication date 1981-01-01
Sub-type Article (original research)
DOI 10.1093/jnci/66.6.1089
Open Access Status
Volume 66
Issue 6
Start page 1089
End page 1096
Total pages 8
Subject 1306 Cancer Research
2730 Oncology
Abstract Cell-mediated immunity and serum regulatory factors were studied in an in vitro system involving a spontaneously regressing, virus-induced tumor. Inbred BALB/c and CBA mice were inoculated with Moloney murine sarcoma virus and their peritoneal cells were tested for reactivity in leukocyte-adherence inhibition tests with extracts of syngeneic tumors. Sera from inoculated mice were tested for their effect on this reactivity. At the optimal dilution, tumor extracts induced significant reactions with cells from tumor-bearing mice (progressors) and from mice with regressed tumors (regressors); cells from normal mice and from mice with transplanted, chemically induced tumors were unaffected. Sera from progressor mice specifically blocked the reactivity of syngeneic cells. At the time of maximal tumor development, this blocking activity disappeared and the serum became unblocking; i.e., the regressor serum neutralized the blocking factor in progressor serum. The blocking and unblocking factors were tumor-specific; no cross-reactivity occurred with similar factors related to the chemically induced tumor. Normal cells were not significantly affected by exposure to blocking and unblocking sera. The development of cellular immune reactivity and serum factors detected in vitro corresponded to the cycle of tumor progression and regression observed in vivo.—JNCI 1981; 66:1089-1096.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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