Effects of oestrogen and bromocryptine on in vivo secretion and mitosis in prolactin cells

Lloyd H.M., Meares J.D. and Jacobi J. (1975) Effects of oestrogen and bromocryptine on in vivo secretion and mitosis in prolactin cells. Nature, 255 5508: 497-498. doi:10.1038/255497a0


Author Lloyd H.M.
Meares J.D.
Jacobi J.
Title Effects of oestrogen and bromocryptine on in vivo secretion and mitosis in prolactin cells
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 1975-01-01
Sub-type Article (original research)
DOI 10.1038/255497a0
Open Access Status Not yet assessed
Volume 255
Issue 5508
Start page 497
End page 498
Total pages 2
Subject 1000 General
Abstract THE response of the rat pituitary gland to oestrogen includes increased mitotic and secretory activity affecting several of the cell types in the anterior lobe but leading in particular to proliferation of prolactin cells 1. Bromocryptine inhibits release of prolactin2,3 and also inhibits DNA synthesis in the oestrogen-stimulated pituitary gland4. In studying the pituitary response to oestrogen during a prolonged period of bromocryptine inhibition, we have observed a close relationship between effects on serum prolactin levels and on pituitary mitotic activity. Our findings lend support to the idea that secretory behaviour influences mitotic activity in prolactin cells4.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 23 Aug 2016, 11:42:44 EST by System User