Effects of capillary heterogeneity on rates of steady uptake of substances by the intact liver

Bass L. and Robinson P.J. (1981) Effects of capillary heterogeneity on rates of steady uptake of substances by the intact liver. Microvascular Research, 22 1: 43-57. doi:10.1016/0026-2862(81)90110-2


Author Bass L.
Robinson P.J.
Title Effects of capillary heterogeneity on rates of steady uptake of substances by the intact liver
Journal name Microvascular Research   Check publisher's open access policy
ISSN 1095-9319
Publication date 1981-01-01
Sub-type Article (original research)
DOI 10.1016/0026-2862(81)90110-2
Open Access Status Not yet assessed
Volume 22
Issue 1
Start page 43
End page 57
Total pages 15
Subject 1303 Specialist Studies in Education
2705 Cardiology and Cardiovascular Medicine
Abstract Steady elimination of substances by a heterogeneous perfused organ is investigated for general uptake kinetics, with special reference to saturation kinetics. In the case of uptake of substances by hepatocellular enzymes according to Michaelis-Menten kinetics, the theory is brought to bear on published data on the elimination of galactose by isolated perfused pig livers. Using a statistical sample-splitting method, it is shown that the data are inconsistent with functional homogeneity of liver sinusoids (P < 0.002), and a reinterpretation of the pooled data is carried through in terms of a model incorporating capillary heterogeneity. The limitations of such analyses in the case of several parallel biochemical pathways of uptake are discussed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 23 Aug 2016, 11:38:43 EST by System User