DNA replication and repair in ataxia telangiectasia cells exposed to bleomycin

Morris C., Mohamed R. and Lavin M.F. (1983) DNA replication and repair in ataxia telangiectasia cells exposed to bleomycin. Mutation Research DNA Repair Reports, 112 2: 67-74. doi:10.1016/0167-8817(83)90011-1


Author Morris C.
Mohamed R.
Lavin M.F.
Title DNA replication and repair in ataxia telangiectasia cells exposed to bleomycin
Journal name Mutation Research DNA Repair Reports
ISSN 0167-8817
Publication date 1983-01-01
Sub-type Article (original research)
DOI 10.1016/0167-8817(83)90011-1
Volume 112
Issue 2
Start page 67
End page 74
Total pages 8
Subject 2700 Medicine
Abstract A marked increase in sensitivity to bleomycin was observed in two ataxia telangiectasia (AT) lymphoblastoid cell lines compared to that in cell lines from two normal individuals. This sensitivity was obtained at two different concentrations of bleomycin. While normal cells showed a rapid recovery of ability to divide, there was no indication of such a recovery in AT cells up to 120 h after bleomycin treatment. A similar level of breakage of DNA occurred in both cell types after incubation with bleomycin. The rate of repair of these breaks was also the same. DNA synthesis was found to be more resistant to bleomycin in AT cells than in control cells. The latter data are in keeping with results previously obtained using ionizing radiation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 23 Aug 2016, 10:50:03 EST by System User