DNA synthesis and secretory activity in parathyroid adenomas

Lloyd H.M., Jacobi J.M., Willgoss D., Kearney J. and Ward P. (1981) DNA synthesis and secretory activity in parathyroid adenomas. Acta Endocrinologica, 96 1: 70-74.

Author Lloyd H.M.
Jacobi J.M.
Willgoss D.
Kearney J.
Ward P.
Title DNA synthesis and secretory activity in parathyroid adenomas
Journal name Acta Endocrinologica   Check publisher's open access policy
ISSN 0001-5598
Publication date 1981-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 96
Issue 1
Start page 70
End page 74
Total pages 5
Language eng
Subject 1310 Endocrinology
Abstract DNA synthesis was measured in vitro by incorporation of ( H)thymidine into DNA in 42 parathyroid chief cell adenomas immediately after surgical removal. The results ranged from 18 to 185 DPM/μg DNA and showed a positive correlation with pre-operative values for serum immunoreactive parathyroid hormone (r = + 0.47; P<0.001) and plasma calcium (r = + 0.35; P<0.05). There was no correlation between DNA synthesis and tumour weight or mean diameter of tumour cell nuclei. The results suggest that DNA synthesis and cell division in parathyroid adenomas are determined in part by the secretory activity of the tumour. DNA synthesis measured on one occasion is not necessarily an overall index of tumour growth.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Tue, 23 Aug 2016, 10:48:27 EST by System User