The packing of spheres in embryogenesis and carcinogenesis

Daunter B. (1986) The packing of spheres in embryogenesis and carcinogenesis. Medical Hypotheses, 21 1: 61-70. doi:10.1016/0306-9877(86)90063-0


Author Daunter B.
Title The packing of spheres in embryogenesis and carcinogenesis
Journal name Medical Hypotheses   Check publisher's open access policy
ISSN 0306-9877
Publication date 1986-01-01
Sub-type Article (original research)
DOI 10.1016/0306-9877(86)90063-0
Volume 21
Issue 1
Start page 61
End page 70
Total pages 10
Subject 1309 Developmental Biology
2700 Medicine
3002 Drug Discovery
Abstract Fertilization of the mammalian ova results in the formation of a compact ball of cells, the morula, which then transforms into a hollow sphere of cells, the blastula. The formation of these structures is considered to be dependent on the number and shape of the cells present and approximates to the problem of maximal sphere packing. Similarly, the shape of organs, to some degree, is considered to be dependent upon the shape of the constituent cells which predetermines their maximal packing densities. Implicit in this concept is that like-cells divide until they reach their maximal packing density and are then inhibited from further replication by three dimensional contact inhibition. In this context, tumour cells may be considered as pleomorphic relative to the tissue in which they arise and form a benign tumour, whereas malignant tumours display pleomorphism within the tumour mass.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 23 Aug 2016, 10:46:38 EST by System User