In vitro studies of gallstone dissolution using bile salt solutions and heparinized saline

Hardie I.R., Green M.K., Burnett W., Wall D.R. and Hall-Brown A. (1977) In vitro studies of gallstone dissolution using bile salt solutions and heparinized saline. British Journal of Surgery, 64 8: 572-576. doi:10.1002/bjs.1800640813


Author Hardie I.R.
Green M.K.
Burnett W.
Wall D.R.
Hall-Brown A.
Title In vitro studies of gallstone dissolution using bile salt solutions and heparinized saline
Journal name British Journal of Surgery   Check publisher's open access policy
ISSN 0007-1323
Publication date 1977-01-01
Sub-type Article (original research)
DOI 10.1002/bjs.1800640813
Open Access Status Not yet assessed
Volume 64
Issue 8
Start page 572
End page 576
Total pages 5
Language eng
Subject 2746 Surgery
Abstract A controlled in vitro study of gallstone dissolution has been carried out using a model designed to simulate the in vivo situation in the bile ducts. Sodium taurocholate, sodium cholate, heparinized saline and physiological saline were infused for 10 days over 81 stones from 32 patients and changes in weight and structure were recorded. The bile salt solutions caused weight loss in 81·5 and 85·7 per cent respectively of the stones treated, but the two saline solutions caused weight gains in 74·5 and 88 per cent respectively. Fragmentation occurred in 18·5 per cent of stones treated with sodium taurocholate, in 25 per cent of those treated with sodium cholate and in 11·8 per cent of those treated with heparinized saline. Small stones lost a lower absolute amount of weight than large stones but this represented a greater proportion of their initial weight. These investigations confirm the advantages of a dynamic in vitro model to study gallstone dissolution. Bile salt solutions infused into the bile ducts may clear retained stones by causing reduction in stone weight or fragmentation or both, but heparinized saline appears to be unsuitable for gallstone dissolution. Larger stones may require longer periods of infusion. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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