The changing prevalence of pulmonary infection in adults with cystic fibrosis: a longitudinal analysis

Ramsay, Kay A., Sandhu, Harpreet, Geake, James B., Ballard, Emma, O'Rourke, Peter, Wainwright, Claire E., Reid, David W., Kidd, Timothy J. and Bell, Scott C. (2016) The changing prevalence of pulmonary infection in adults with cystic fibrosis: a longitudinal analysis. Journal of Cystic Fibrosis, 16 1: 70-77. doi:10.1016/j.jcf.2016.07.010


Author Ramsay, Kay A.
Sandhu, Harpreet
Geake, James B.
Ballard, Emma
O'Rourke, Peter
Wainwright, Claire E.
Reid, David W.
Kidd, Timothy J.
Bell, Scott C.
Title The changing prevalence of pulmonary infection in adults with cystic fibrosis: a longitudinal analysis
Journal name Journal of Cystic Fibrosis   Check publisher's open access policy
ISSN 1569-1993
1873-5010
Publication date 2016-08-08
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.jcf.2016.07.010
Open Access Status Not yet assessed
Volume 16
Issue 1
Start page 70
End page 77
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
2740 Pulmonary and Respiratory Medicine
Abstract Background Increased patient longevity and aggressive antibiotic treatment are thought to impact on the microbial composition of the airways of adults with cystic fibrosis (CF). In this study, we sought to determine if a temporal change in the airway microbiology of adults with CF has occurred over time. Methods Longitudinal analysis of sputum microbiology results was undertaken on patients attending a large adult CF centre. Clinical status and health outcomes of transitioning patients were also assessed. Results A decrease in the prevalence of Pseudomonas aeruginosa, Staphylococcus aureus, Burkholderia cepacia complex and Aspergillus spp. (p = 0.001, p < 0.001, p = 0.002 and p < 0.001, respectively) occurred. Improvements in lung function among transitioning patients infected with P. aeruginosa were observed. Conclusion Overtime, a decline in the prevalence of many CF airway pathogens has occurred. Significantly, an incremental improvement in lung function was reported for transitioning patients with current P. aeruginosa infections.
Formatted abstract
Background: Increased patient longevity and aggressive antibiotic treatment are thought to impact on the microbial composition of the airways of adults with cystic fibrosis (CF). In this study, we sought to determine if a temporal change in the airway microbiology of adults with CF has occurred over time.

Methods: Longitudinal analysis of sputum microbiology results was undertaken on patients attending a large adult CF centre. Clinical status and health outcomes of transitioning patients were also assessed.

Results: A decrease in the prevalence of Pseudomonas aeruginosa, Staphylococcus aureus, Burkholderia cepacia complex and Aspergillus spp. (p = 0.001, p < 0.001, p = 0.002 and p < 0.001, respectively) occurred. Improvements in lung function among transitioning patients infected with P. aeruginosa were observed.

Conclusion: Overtime, a decline in the prevalence of many CF airway pathogens has occurred. Significantly, an incremental improvement in lung function was reported for transitioning patients with current P. aeruginosa infections.
Keyword Lung function
Paediatric
Prevalence
Pseudomonas aeruginosa
Transition
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID GNT1088448
600368
Institutional Status UQ

 
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Created: Fri, 19 Aug 2016, 20:20:38 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences