Assessing stability in mild and moderate Parkinson’s disease: can clinical measures provide insight?

Hubble, Ryan P., Silburn, Peter A., Naughton, Geraldine A. and Cole, Michael H. (2016) Assessing stability in mild and moderate Parkinson’s disease: can clinical measures provide insight?. Gait and Posture, 49 7-13. doi:10.1016/j.gaitpost.2016.06.002

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Author Hubble, Ryan P.
Silburn, Peter A.
Naughton, Geraldine A.
Cole, Michael H.
Title Assessing stability in mild and moderate Parkinson’s disease: can clinical measures provide insight?
Journal name Gait and Posture   Check publisher's open access policy
ISSN 0966-6362
Publication date 2016-09-01
Sub-type Article (original research)
DOI 10.1016/j.gaitpost.2016.06.002
Open Access Status File (Author Post-print)
Volume 49
Start page 7
End page 13
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract This cross-sectional study aimed to investigate the relationship between accelerometer-derived measures of movement rhythmicity and clinical measures of mobility, balance confidence and gait difficulty in people with Parkinson’s disease (PD). Twenty-nine independently-living PD patients (Hoehn & Yahr Stages 1–3) with no history of significant injury or orthopaedic/deep brain stimulation surgery were recruited from a database of patients who had expressed an interest to participate in research. Participants completed clinical assessments of mobility, postural stability, balance confidence and symptom severity, while head and trunk rhythmicity was evaluated during gait using accelerometers. Following data collection, patients were stratified based on disease stage into either a Mild (Hoehn & Yahr Stage 1) or Moderate (Hoehn & Yahr Stages 2–3) PD group. The results highlighted that the Moderate PD group had poorer quality of life, reduced balance confidence and increased gait and falls difficulty. Furthermore, for these patients, gait disability and the number of previous falls were both negatively correlated with multiple components of head and trunk rhythmicity. For the Mild PD group, six-meter walk time was positively correlated with ML head rhythmicity and linear regression highlighted a significant predictive relationship between these outcomes. For the Mild and Moderate PD groups, balance confidence respectively predicted anterior-posterior trunk rhythmicity and vertical head rhythmicity. While these findings demonstrate that falls history and the Gait and Falls questionnaire provide moderate insight into head and trunk rhythmicity in Moderate PD patients, objective and clinically-feasible measures of postural instability would assist with the management of these symptoms.
Keyword Parkinson’s disease
Motor control
Quality of life
Postural stability
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 19 Aug 2016, 02:28:02 EST by Susan Day on behalf of Queensland Brain Institute