Separation of dipeptides on a reverse-phase column: effect of non-linear intrinsic adsorption kinetics

Nguyen T.S., Hu S.-G. and Do D.D. (1992) Separation of dipeptides on a reverse-phase column: effect of non-linear intrinsic adsorption kinetics. The Chemical Engineering Journal, 49 3: . doi:10.1016/0300-9467(92)80056-G


Author Nguyen T.S.
Hu S.-G.
Do D.D.
Title Separation of dipeptides on a reverse-phase column: effect of non-linear intrinsic adsorption kinetics
Journal name The Chemical Engineering Journal
ISSN 0300-9467
Publication date 1992-01-01
Sub-type Article (original research)
DOI 10.1016/0300-9467(92)80056-G
Volume 49
Issue 3
Total pages 1
Subject 2200 Engineering
Abstract Based on experimental results for the system of dipeptides (CBZ-leucyl-glycine and CBZ-glycyl-phenylalanine) on reverse-phase silica C18, a detailed rate model including the intrinsic adsorption kinetics is proposed for multicomponent liquid chromatography. Simulation of the model was performed to investigate the effects of various parameters (rate constants, adsorption affinity, sorbent capacity, axial dispersion, feed concentration, sample size and velocity) on the band shape and spreading of elution chromatography. For cases with a finite rate of interaction between adsorbate and adsorbent, the mean retention time for the elution profiles of solutes is still determined by the equilibrium parameters, while the separation (resolution) between solute bands is largely influenced by the rate constants of the intrinsic adsorption kinetics. The effect of intrinsic adsorption kinetics becomes pre-eminent when the superficial velocity Vf is high. An optimal resolution diagram is presented to facilitate determination of the optimal operation parameters for touching-band separation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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