Hexoprenaline: β‐adrenoreceptor selectivity in isolated tissues from the guinea‐pig

O'Donnell S.R. and Wanstall J.C. (1975) Hexoprenaline: β‐adrenoreceptor selectivity in isolated tissues from the guinea‐pig. Clinical and Experimental Pharmacology and Physiology, 2 6: 541-547. doi:10.1111/j.1440-1681.1975.tb01859.x


Author O'Donnell S.R.
Wanstall J.C.
Title Hexoprenaline: β‐adrenoreceptor selectivity in isolated tissues from the guinea‐pig
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 1440-1681
Publication date 1975-01-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.1975.tb01859.x
Volume 2
Issue 6
Start page 541
End page 547
Total pages 7
Subject 1314 Physiology
3004 Pharmacology
2737 Physiology (medical)
Abstract 1. A catecholamine β‐adrenoreceptor agonist, hexoprenaline, was examined in vitro on five guinea‐pig tissues and its potency relative to isoprenaline (as 100) obtained. 2. Hexoprenaline clearly delineated between those tissues classified as containing β2‐adrenoreceptors (trachea, hind limb blood vessels and uterus; relative potencies 219, 110 and 76 respectively) and those classified as containing β1‐adrenoreceptors (atria and ileum; relative potencies 3·3 and 1·0 respectively). 3. Hexoprenaline differed from some previously studied noncatecholamine β‐adrenoreceptor agonists in being only two‐fold less potent, relative to isoprenaline, as a vasodilator in perfused hind limb than as a tracheal relaxant. Copyright
Keyword blood vessels
bronchodilators
guinea‐pig
hexoprenaline
selectivity
trachea
β‐adrenoreceptors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 16 Aug 2016, 14:30:28 EST by System User