ATP mediates an excitatory noradrenergic neuron input to supraoptic vasopressin cells

Day T.A., Sibbald J.R. and Khanna S. (1993) ATP mediates an excitatory noradrenergic neuron input to supraoptic vasopressin cells. Brain Research, 607 1-2: 341-344. doi:10.1016/0006-8993(93)91528-Z


Author Day T.A.
Sibbald J.R.
Khanna S.
Title ATP mediates an excitatory noradrenergic neuron input to supraoptic vasopressin cells
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
Publication date 1993-04-02
Sub-type Article (original research)
DOI 10.1016/0006-8993(93)91528-Z
Open Access Status
Volume 607
Issue 1-2
Start page 341
End page 344
Total pages 4
Subject 1309 Developmental Biology
1312 Molecular Biology
2728 Clinical Neurology
2800 Neuroscience
Abstract Although A1 noradrenaline (NA) neurons of the caudal medulla provide a direct, excitatory input to supraoptic vasopressin cells, they do not use NA as their primary transmitter. We have now tested the possibility that adenosine 5′-triphosphate (ATP) may fulfill this role. Extracellular recordings from rat supraoptic nucleus demonstrated that locally applied ATP excites neurosecretory vasopressin cells and that this effect is mimicked by the ATP receptor-agonist α, β-methylene ATP and blocked by the ATP receptor-blocker suramin. Suramin did not block the excitatory effect of locally applied NA on vasopressin cells but did block excitations produced by vagus nerve stimulation, such excitations having previously been shown to involve a pathway in which the final relay is an input from the A1 cell group. These results indicate that certain central NA neurons use ATP as a transmitter and also provide the first demonstration of a specific physiological role for central purinergic neurons, i.e. regulation of secretion of the neurohormone vasopressin.
Keyword A1 cell group
Neurosecretory cell
Noradrenergic neuron
Purinergic transmission
Supraoptic nucleus
Vasopressin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 74 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 16 Aug 2016, 14:29:25 EST by System User