Locus coeruleus effects on baroreceptor responsiveness and activity of neurosecretory vasopressin cells

Day T.A. and Sibbald J.R. (1993) Locus coeruleus effects on baroreceptor responsiveness and activity of neurosecretory vasopressin cells. Journal of the Autonomic Nervous System, 42 3: 259-263. doi:10.1016/0165-1838(93)90371-Z


Author Day T.A.
Sibbald J.R.
Title Locus coeruleus effects on baroreceptor responsiveness and activity of neurosecretory vasopressin cells
Journal name Journal of the Autonomic Nervous System   Check publisher's open access policy
ISSN 0165-1838
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1016/0165-1838(93)90371-Z
Volume 42
Issue 3
Start page 259
End page 263
Total pages 5
Subject 1314 Physiology
2728 Clinical Neurology
2800 Neuroscience
Abstract The locus coeruleus (LC) has previously been implicated in the regulation of vasopressin secretion. To further investigate this issue experiments were done in which extracellular recordings were obtained from functionally identified neurosecretory vasopressin (VP) cells of the rat supraoptic nucleus. Electrolytic lesions of the ipsilateral LC reduced the proportion of VP cells inhibited by carotid baroreceptor activation from 93% to 35%; the inhibitory effect of aortic depressor nerve stimulation was unchanged. Electrical stimulation of the LC altered the discharge probability of 20% of VP cells tested, the predominant effect being excitation. In contrast to the effects of electrolytic lesions and electrical stimulation, neither chemical inhibition nor stimulation of the LC, by local injection of neuroactive amino acids, altered VP cell baroreceptor responsiveness or spontaneous discharge. These data indicate that while fibres of passage in the LC region can influence VP cell excitability, particularly responses to carotid baroreceptor activation, LC cells do not regulate VP cell function or, by implication, the secretion of this vasoactive and antidiuretic hormone.
Keyword A6 cell group
Baroreceptor
Locus coeruleus
Neurosecretory cell
Supraoptic nucleus
Vasopressin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 16 Aug 2016, 14:28:03 EST by System User