Diagnosis of hemochromatosis in young subjects: Predictive accuracy of biochemical screening tests

Bassett M.L., Halliday J.W., Ferris R.A. and Powell L.W. (1984) Diagnosis of hemochromatosis in young subjects: Predictive accuracy of biochemical screening tests. Gastroenterology, 87 3: 628-633.

Author Bassett M.L.
Halliday J.W.
Ferris R.A.
Powell L.W.
Title Diagnosis of hemochromatosis in young subjects: Predictive accuracy of biochemical screening tests
Journal name Gastroenterology   Check publisher's open access policy
ISSN 0016-5085
Publication date 1984-01-01
Sub-type Article (original research)
Volume 87
Issue 3
Start page 628
End page 633
Total pages 6
Subject 2715 Gastroenterology
Abstract The reliability of serum iron, transferrin saturation, and serum ferritin in the detection of early iron overload in hemochromatosis was determined in 120 young (<35 yr old) relatives whose genetic susceptibility for the disease was determined by HLA typing of families. Serum ferritin and transferrin saturation demonstrated high levels of sensitivity and specificity, whereas serum iron concentration was an unreliable test in the detection of hemochromatosis. In hemochromatosis homozygotes there was an excellent correlation between serum ferritin and mobilized body iron (r = 0.92), 1 μg/L of serum ferritin corresponding to ~7.5 mg of body iron stores. For a given age, serum ferritin values were higher in homozygotes compared with heterozygotes or homozygous-normal subjects and increased by ~65 μg/L · yr, reflecting the progressive accumulation of iron in hemochromatosis homozvgotes. All hemochromatosis subjects with either hepatic fibrosis or cirrhosis had serum ferritin concentrations >700 μg/L. We conclude that the combination of serum ferritin and transferrin saturation is a reliable screening regimen for the detection of hemochromatosis and for predicting the level of body iron stores in young hemochromatosis subjects.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 129 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 16 Aug 2016, 14:13:39 EST by System User