Immune response: Tissue specific T-lymphocytes

Daunter B. (1992) Immune response: Tissue specific T-lymphocytes. Medical Hypotheses, 37 2: 76-84. doi:10.1016/0306-9877(92)90044-D

Author Daunter B.
Title Immune response: Tissue specific T-lymphocytes
Journal name Medical Hypotheses   Check publisher's open access policy
ISSN 0306-9877
Publication date 1992-01-01
Sub-type Article (original research)
DOI 10.1016/0306-9877(92)90044-D
Volume 37
Issue 2
Start page 76
End page 84
Total pages 9
Language eng
Subject 1309 Developmental Biology
2700 Medicine
3002 Drug Discovery
Abstract The lymphatic system forms a 'blind' plexus of vessels that in general are found in tissue which has an inherently high replicative capacity. It is this system that is responsible for the rapid deployment and circulation of tissue-specific T-lymphocytes for the inspection of cell-surface aberrations within the tissue. The presence of tissue-specific T-lymphocytes explains why 90% of lymphocytes are found outside the lymphatic system and why they migrate in a selective manner. The tissue-specific T-lymphocyte is considered to express a common lymphocyte cell surface pattern, the homotype, and a tissue-specific cell-surface pattern, the histotype which may involve MHCA and mHCA. It is the histotypic pattern that is responsible for the tissue specificity of the tissue-specific T-lymphocyte. The presence of tissue-specific T-lymphocytes does pose problems for the immune system. If different tissue-specific T-lymphocytes met within a particular tissue, 'lost' lymphocytes, an immune response will be generated against the intruder (lost lymphocyte), and the intruder will not be able to recruit other immunocompetent cells in that tissue. This immune reaction is an attempt to change the histotypic pattern of the intruder. This situation would explain the autologous immune response. This response however is suppressed in the systemic system by immunosuppressive compounds from the liver. It is only in the tissues that the tissue-specific T-lymphocytes are released from this suppression, in order to initiate immune reactions against aberrant cell-surface patterns.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 16 Aug 2016, 14:12:50 EST by System User