Immunology of pregnancy: towards a unifying hypothesis

Daunter B. (1992) Immunology of pregnancy: towards a unifying hypothesis. European Journal of Obstetrics and Gynecology and Reproductive Biology, 43 2: 81-95. doi:10.1016/0028-2243(92)90064-6


Author Daunter B.
Title Immunology of pregnancy: towards a unifying hypothesis
Journal name European Journal of Obstetrics and Gynecology and Reproductive Biology   Check publisher's open access policy
ISSN 0028-2243
Publication date 1992-01-31
Sub-type Article (original research)
DOI 10.1016/0028-2243(92)90064-6
Open Access Status
Volume 43
Issue 2
Start page 81
End page 95
Total pages 15
Subject 2729 Obstetrics and Gynaecology
2743 Reproductive Medicine
Abstract The variable findings of hormonal-immunoregulation and the variable cellular and humoral immune responses in pregnancy have been considered in relationship to the physiological response. From such considerations it appears that the peripheral blood lymphocyte/leukocyte response in pregnancy is not important, but rather the local uterine immune response at implantation and throughout pregnancy. It is proposed, and evidence is presented, that a normal allogeneic immune response is initiated at the time of implantation of the blastocyst. This immune response regulates the invasive nature of the trophoblast and initiates the first stage of parturition. The initiation and maintenance of this immune response is based on an interplay between maternal and paternal HLA and trophoblast antigens. In the case of HLA-incompatible donor-recipient blastocyst transplants, a more pivotal role for immunoregulation by trophoblast antigens is proposed. This is because it is considered that the local uterine immune response suppresses the expression of allogeneic HLA. This concept is further developed in terms of haploid HLA suppression on maternal and fetal lymphocytes that cross the placenta. This is considered to allow the interaction of these lymphocytes with each other and explains maternal transfer of cell-mediated immunity.
Keyword Fetal
Immune response
Maternal
Pregnancy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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