The effects of certain vasodilating prostaglandins on the coronary and hindlimb vascular beds of the conscious sheep

Carter J., Reynoldson J.A. and Thorburn G.D. (1986) The effects of certain vasodilating prostaglandins on the coronary and hindlimb vascular beds of the conscious sheep. Comparative Biochemistry and Physiology. Part C, Comparative, 83 2: 401-406. doi:10.1016/0742-8413(86)90143-X


Author Carter J.
Reynoldson J.A.
Thorburn G.D.
Title The effects of certain vasodilating prostaglandins on the coronary and hindlimb vascular beds of the conscious sheep
Journal name Comparative Biochemistry and Physiology. Part C, Comparative   Check publisher's open access policy
ISSN 0306-4492
Publication date 1986-01-01
Sub-type Article (original research)
DOI 10.1016/0742-8413(86)90143-X
Volume 83
Issue 2
Start page 401
End page 406
Total pages 6
Subject 2403 Immunology
3004 Pharmacology
Abstract 1. Vasodilating prostaglandins were injected, in bolus doses, into the lower abdominal aorta or left circumflex coronary artery (LCCA) of conscious sheep. 2. Local blood flow. mean arterial pressure (MAP), heart rate (HR) and ECG were monitored continuously. 3. 6-Keto PGF1α had no effect on either vascular bed in doses up to 100 μg. PGE2 was more potent than PGI2in dilating hindlimb vasculature and PGE2 induced a more persistent hyperaemia whereas PGD2 elicited a biphasic response (constriction -dilation). 4. PGE1, PGE2, PGD2 and PGI2 all produced dose-dependent vasodilation, the order of potency being PGD2 > PGI2>PGE1≥ PGE2. The effect of PGI2 was more transient and PGE1 and PGD2 caused small but consistent decreases in MAP and HR, respectively.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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