Serial D-dimer levels in the assessment of tumor mass and clinical outcome in ovarian cancer

Khoo S.K., Rylatt D.B., Parsons P., Wilson K., Webb M.J., Dickie G., Kearsley J. and Mackay E.V. (1988) Serial D-dimer levels in the assessment of tumor mass and clinical outcome in ovarian cancer. Gynecologic Oncology, 29 2: 188-198. doi:10.1016/0090-8258(88)90213-2


Author Khoo S.K.
Rylatt D.B.
Parsons P.
Wilson K.
Webb M.J.
Dickie G.
Kearsley J.
Mackay E.V.
Title Serial D-dimer levels in the assessment of tumor mass and clinical outcome in ovarian cancer
Journal name Gynecologic Oncology   Check publisher's open access policy
ISSN 1095-6859
Publication date 1988-01-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/0090-8258(88)90213-2
Volume 29
Issue 2
Start page 188
End page 198
Total pages 11
Publisher NATURE PUBLISHING GROUP
Language eng
Subject 2729 Obstetrics and Gynaecology
2730 Oncology
Abstract D-dimer (DD)-an end product of fibrinolysis-was measured in serum by enzyme immunoassay using a monoclonal antibody to the γγ crosslink in patients with ovarian cancer, before primary surgery and during chemotherapy for 12 months or more. Serial DD levels were found to have a high sensitivity for the detection of tumor in patients with subclinical disease (91%) as well as for predicting progression of disease (100%). As determined by a careful second-look laparotomy in patients with complete clinical remission the DD marker was highly predictive of tumors < 1 cm. The negative predictive value (82%) was higher than the positive predictive value (69%). However, there were 31% of the patients who showed a false-positive result; a close examination of the clinical data of these 9 patients failed to reveal an explanation for the positive DD levels. Despite the lack of specificity (50% in the present series), the findings support the use of DD in the assessment of patients with ovarian cancer, especially those with subclinical disease.
Keyword Biochemistry & Molecular Biology
Oncology
Cell Biology
Genetics & Heredity
Biochemistry & Molecular Biology
Oncology
Cell Biology
Genetics & Heredity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID C191591/A6181
C38302/A12278
WT093326MA
BB/L007096/1
626791
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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