c-Fos expression in hypothalamic neurosecretory and brainstem catecholamine cells following noxious somatic stimuli

Smith D.W. and Day T.A. (1994) c-Fos expression in hypothalamic neurosecretory and brainstem catecholamine cells following noxious somatic stimuli. Neuroscience, 58 4: 765-775. doi:10.1016/0306-4522(94)90453-7


Author Smith D.W.
Day T.A.
Title c-Fos expression in hypothalamic neurosecretory and brainstem catecholamine cells following noxious somatic stimuli
Journal name Neuroscience   Check publisher's open access policy
ISSN 0306-4522
Publication date 1994-01-01
Sub-type Article (original research)
DOI 10.1016/0306-4522(94)90453-7
Volume 58
Issue 4
Start page 765
End page 775
Total pages 11
Subject 2800 Neuroscience
Abstract Noxious somatic stimuli elicit vasopressin secretion, an effect thought to result from activation of a facilitatory input from Al catecholamine cells of the medulla oblongata. To better characterize the Al cell response and effects on other neuroendocrine Al projection targets, particularly within the paraventricular nucleus, we have now mapped c-fos expression in neurochemically identified catecholamine and neurosecretory cells following a noxious somatic stimulus. Unilateral hind paw pinch significantly increased c-fos expression in contralateral Al cells whereas other brainstem catecholamine cell groups were unaffected. Expression of c-fos was also increased in the supraoptic nucleus, this effect being more pronounced for vasopressin than oxytocin neurosecretory cells and, as with Al cells, primarily on the side contralateral to the stimulated paw. In contrast, the increase in the paraventricular nucleus was greater in oxytocin rather than in vasopressin cells. Additionally there was a significant rise in c-fos expression in medial parvocellular paraventricular nucleus cells of noxiously stimulated animals. Notably, the majority of tuberoinfundibular corticotropin-releasing factor cells are located in this medial parvocellular zone. These results are consistent with and expand on those previously reported from electrophysiological and anatomical studies. The finding of differing neurosecretory cell responses between supraoptic and paraventricular nuclei has interesting implications with regard to the afferent control of neurosecretory cell activity. For example, the substantially greater activation of supraoptic versus paraventricular nucleus vasopressin cells, despite being innervated by the same medullary noradrenergic cell group, raises the possibility of a differential input or differences in responsiveness. Furthermore, the activation of paraventricular nucleus parvocellular cells is consistent with suggestions that the Al cell group provides an excitatory input to this population.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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