Salicylate metabolite kinetics after several salicylates

Bochner F., Graham G.G., Cham B.E., Imhoff D.M. and Haavisto T.M. (1981) Salicylate metabolite kinetics after several salicylates. Clinical Pharmacology and Therapeutics, 30 2: 266-275.

Author Bochner F.
Graham G.G.
Cham B.E.
Imhoff D.M.
Haavisto T.M.
Title Salicylate metabolite kinetics after several salicylates
Journal name Clinical Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0009-9236
Publication date 1981-01-01
Sub-type Article (original research)
Volume 30
Issue 2
Start page 266
End page 275
Total pages 10
Subject 3004 Pharmacology
Abstract Single oral doses of aspirin (ASA, 1,500 mg), sodium salicylate (NaSA, 1,500 mg, 1,200 mg), and salicyluric acid (SUA, 500 mg) were given to five subjects. Serial plasma and urine samples were collected for 24 hr (plasma) and up to 48 hr (urine); salicylic acid (SA), SUA, and gentisic acid (GA) were measured by high-pressure liquid chromatography. The plasma concentration/time profiles for SUA after ASA and NaSA were fitted to the empirical equation CpSUA = A-Bt-Ce-αt - (A-C)e-βt. Michaelis constants (Vm and Km) for the conversion of SA to SUA were calculated from the equation cl[cpSUA+ l ke· dCpSUA dt]= Vm CpSA km+CpSA, where Cl is the renal clearance of SUA, ke is the rate constant of elimination of SUA, CpSA is the plasma concentration of salicylic acid. The term cl[cpSUA+ l ke· dCpSUA dt] is the estimated rate of formation of SUA from SA at any time (t). The calculated values (mean ± SD) of Vm, Km, and Kmf (Km in terms of unbound SA) were 43.4 ± 10.1 mg SA/hr, 14.3 ± 3.4 mg SA/l plasma, and 0.75 ± 0.15 mg unbound SA/l plasma. The Vm values were in accord with those reported, but the value for Km was considerably lower. Renal clearances of SUA and GA were 340 ± 51 and 65 ± 10 ml/min.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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