Suppression of renin secretion in the isolated rat kidney by cycloheximide

Vandongen R. (1976) Suppression of renin secretion in the isolated rat kidney by cycloheximide. European Journal of Pharmacology, 40 1: 179-181. doi:10.1016/0014-2999(76)90368-X


Author Vandongen R.
Title Suppression of renin secretion in the isolated rat kidney by cycloheximide
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 1976-01-01
Sub-type Article (original research)
DOI 10.1016/0014-2999(76)90368-X
Volume 40
Issue 1
Start page 179
End page 181
Total pages 3
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
Abstract The effect of cycloheximide, an inhibitor of protein synthesis, on basal and stimulated renin secretion was examined in the isolated perfused rat kidney. Cycloheximide (0.05 mmol) was administered one hour before preparing the kidneys for perfusion. Both basal renin secretion and the response to intrarenal infusion of isoprenaline (0.06 nmol/min/g) or glucagon (0.1 nmol/min/g) were consistently reduced in the cycloheximide-treated group, suggesting dependence of these processes on protein synthesis.
Keyword Cycloheximide
Glucagon
Isolated rat kidney
Isoprenaline
Renin secretion
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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