The renal handling of diphenylhydantoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin

Bochner F., Hooper W.D., Sutherland J.M., Eadie M.J. and Tyrer J.H. (1973) The renal handling of diphenylhydantoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin. Clinical Pharmacology and Therapeutics, 14 5: 791-796.

Author Bochner F.
Hooper W.D.
Sutherland J.M.
Eadie M.J.
Tyrer J.H.
Title The renal handling of diphenylhydantoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin
Journal name Clinical Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0009-9236
Publication date 1973-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 14
Issue 5
Start page 791
End page 796
Total pages 6
Subject 3004 Pharmacology
2736 Pharmacology (medical)
Abstract The renal clearances of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH) have been measured in groups of 16 and 14 ambulant epileptic patients, respectively. All patients had normal renal function (creatinine clearances, 83 to 148 ml per minute), and were taking oral diphenylhydantoin sodium in doses of 300 to 500 mg per day. DPH clearance (3 to 23 ml per minute, depending on urine flow rate) was considerably less than that expected for inulin, and it seems probable that DPH undergoes net resorption in its passage through the kidney. HPPH clearance (76 to 420 ml per minute depending on urine flow rate) exceeded expected inulin clearance if urine flow rates were sufficiently high, allowing the suggestion that net secretion of HPPH occurs during its passage through the nephron. Although the clearances of both compounds increase with urine flow rate, it is concluded that neither oliguria nor polyuria would be likely to greatly influence plasma DPH concentration in the short term, making dosage adjustment in these two circumstances unnecessary, at least as a matter of urgency.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 16 Aug 2016, 12:09:27 EST by System User