Flux ratio theorems for nonstationary membrane transport with temporary capture of tracer

Bass L., Bracken A.J. and Hilden J. (1986) Flux ratio theorems for nonstationary membrane transport with temporary capture of tracer. Journal of Theoretical Biology, 118 3: 327-338. doi:10.1016/S0022-5193(86)80063-7


Author Bass L.
Bracken A.J.
Hilden J.
Title Flux ratio theorems for nonstationary membrane transport with temporary capture of tracer
Journal name Journal of Theoretical Biology   Check publisher's open access policy
ISSN 1095-8541
Publication date 1986-02-07
Sub-type Article (original research)
DOI 10.1016/S0022-5193(86)80063-7
Open Access Status Not yet assessed
Volume 118
Issue 3
Start page 327
End page 338
Total pages 12
Subject 1100 Agricultural and Biological Sciences
1300 Biochemistry, Genetics and Molecular Biology
2400 Immunology and Microbiology
2604 Applied Mathematics
2611 Modelling and Simulation
2613 Statistics and Probability
2700 Medicine
Abstract It has been shown recently that the ratio of unidirectional tracer fluxes, passing in opposite directions through a membrane which has transport properties varying arbitrarily with the distance from a boundary, is independent of time from the very first appearance of the two outfluxes from the membrane. This surprising proposition has been proved for boundary conditions defining standard unidirectional fluxes, and then generalized to classes of time-dependent boundary conditions. The operational meaning of all the resulting theorems is that when any of them appear to be refuted experimentally, the presence of more than one parallel transport pathway (that is, of membrane heterogeneity transverse to the direction of transport) can be inferred and analyzed. Recent experimental data have been interpreted accordingly. However, the proofs of the theorems given so far have not taken into account the possibility of temporary capture of tracer at sites fixed in the membrane (including also entrances to microscopic culs-de-sac). The possible presence of such a process, which would not affect fluxes in the steady state, left a fundamental gap in the aforementioned inferences. It is shown here that all the theorems previously proved for the flux ratio under unsteady conditions remain valid when temporary capture of tracer is admitted, no matter how the rate of capture, and the probability distribution of residence times of tracer at capture sites, may depend on the distance from a membrane boundary. The validity of the aforementioned inferences from observed time-dependence of the flux ratio is thereby extended to a much wider class of membrane transport processes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 17 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 16 Aug 2016, 11:53:59 EST by System User