CD4 and CD8 may adopt a similar mode of binding to their MHC ligands

Brinkworth R.I. (1992) CD4 and CD8 may adopt a similar mode of binding to their MHC ligands. Protein Engineering, Design and Selection, 5 2: 151-155. doi:10.1093/protein/5.2.151


Author Brinkworth R.I.
Title CD4 and CD8 may adopt a similar mode of binding to their MHC ligands
Journal name Protein Engineering, Design and Selection   Check publisher's open access policy
ISSN 1741-0126
Publication date 1992-01-01
Sub-type Article (original research)
DOI 10.1093/protein/5.2.151
Volume 5
Issue 2
Start page 151
End page 155
Total pages 5
Subject 3004 Pharmacology
2800 Neuroscience
2400 Immunology and Microbiology
1312 Molecular Biology
1502 Banking, Finance and Investment
1305 Biotechnology
1303 Specialist Studies in Education
Abstract A theoretical scheme is proposed by which the type-specific cell surface receptors of T-lymphocytes, CD8 and CD4, bind class I and II MHC proteins in a similar manner. The scheme has equivalent residues in the C'/C" loop-C" strand-C"/D loop region in domain 1 of CD4 and CD8α binding to equivalent residues in the C and D β-strands and C/D loops in HLA-DRβ2 (class II) and HLA-A2α3 (class I) respectively through a series of electrostatic, hydrogen and hydrophobic bonds.
Keyword CD4
CD8
HLA-A2
HLA-DR
Major histocompatibility
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 16 Aug 2016, 11:44:19 EST by System User